Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial

The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-u...

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Autores: Navarro López, Vicente, Martínez Andrés, A., Ramírez Boscá, Ana, Ruzafa Costas, Beatriz, Núñez Delegido, Eva, Carrión Gutiérrez, Miguel Ángel, Prieto Merino, David, Codoñer Cortés, F., Ramón Vidal, Daniel, Genovés Martínez, Salvador, Chenoll Cuadros, E., Pérez Orquín, José Manuel, Picó Monllor, JA, Chumillas Lidón, S.
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Católica San Antonio de Murcia (UCAM)
Repositorio:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
OAI Identifier:oai:repositorio.ucam.edu:10952/8976
Acceso en línea:http://hdl.handle.net/10952/8976
Access Level:acceso abierto
Palabra clave:Dermatology
Microbiome
Microbiota
Probiotics
Psoriasis.
Psoriasis
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spelling Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical TrialNavarro López, VicenteMartínez Andrés, A.Ramírez Boscá, AnaRuzafa Costas, BeatrizNúñez Delegido, EvaCarrión Gutiérrez, Miguel ÁngelPrieto Merino, DavidCodoñer Cortés, F.Ramón Vidal, DanielGenovés Martínez, SalvadorChenoll Cuadros, E.Pérez Orquín, José ManuelPicó Monllor, JAChumillas Lidón, S.DermatologyMicrobiomeMicrobiotaProbioticsPsoriasis.PsoriasisThe aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.MedicinaMedicina2019info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/8976reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/89762026-06-07T18:35:21Z
dc.title.none.fl_str_mv Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
spellingShingle Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
Navarro López, Vicente
Dermatology
Microbiome
Microbiota
Probiotics
Psoriasis.
Psoriasis
title_short Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_full Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_fullStr Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_full_unstemmed Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_sort Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
dc.creator.none.fl_str_mv Navarro López, Vicente
Martínez Andrés, A.
Ramírez Boscá, Ana
Ruzafa Costas, Beatriz
Núñez Delegido, Eva
Carrión Gutiérrez, Miguel Ángel
Prieto Merino, David
Codoñer Cortés, F.
Ramón Vidal, Daniel
Genovés Martínez, Salvador
Chenoll Cuadros, E.
Pérez Orquín, José Manuel
Picó Monllor, JA
Chumillas Lidón, S.
author Navarro López, Vicente
author_facet Navarro López, Vicente
Martínez Andrés, A.
Ramírez Boscá, Ana
Ruzafa Costas, Beatriz
Núñez Delegido, Eva
Carrión Gutiérrez, Miguel Ángel
Prieto Merino, David
Codoñer Cortés, F.
Ramón Vidal, Daniel
Genovés Martínez, Salvador
Chenoll Cuadros, E.
Pérez Orquín, José Manuel
Picó Monllor, JA
Chumillas Lidón, S.
author_role author
author2 Martínez Andrés, A.
Ramírez Boscá, Ana
Ruzafa Costas, Beatriz
Núñez Delegido, Eva
Carrión Gutiérrez, Miguel Ángel
Prieto Merino, David
Codoñer Cortés, F.
Ramón Vidal, Daniel
Genovés Martínez, Salvador
Chenoll Cuadros, E.
Pérez Orquín, José Manuel
Picó Monllor, JA
Chumillas Lidón, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dermatology
Microbiome
Microbiota
Probiotics
Psoriasis.
Psoriasis
topic Dermatology
Microbiome
Microbiota
Probiotics
Psoriasis.
Psoriasis
description The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10952/8976
url http://hdl.handle.net/10952/8976
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
instname:Universidad Católica San Antonio de Murcia (UCAM)
instname_str Universidad Católica San Antonio de Murcia (UCAM)
reponame_str RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
collection RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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