Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems

In the present thesis, it is demonstrated the potential of fluid bed top-spray technology as an alternative to spray drying for the production of amorphous solid dispersions (ASDs) intended for immediate drug release systems, i.e. tablets. Comparative analysis of ASDs physical properties, stability,...

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Detalles Bibliográficos
Autor: Fradera Gelabert, Sara
Tipo de recurso: tesis doctoral
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/34496
Acceso en línea:http://hdl.handle.net/10347/34496
Access Level:acceso abierto
Palabra clave:320908 Preparación de medicamentos
320902 Composición de medicamentos
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spelling Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systemsFradera Gelabert, Sara320908 Preparación de medicamentos320902 Composición de medicamentosIn the present thesis, it is demonstrated the potential of fluid bed top-spray technology as an alternative to spray drying for the production of amorphous solid dispersions (ASDs) intended for immediate drug release systems, i.e. tablets. Comparative analysis of ASDs physical properties, stability, and dissolution profiles obtained via both technologies were conducted. The effect of formulation variables, using fluid bed, was evaluated guided by a Quality by Design (QbD) approach. Finally, three ASD-based prototypes produced using fluid bed top-spray and different polymeric carriers (HPMCAS-MG and HPMCP HP-55) were developed followed by an in vivo pilot bioavailability study comparing their pharmacokinetic behaviour with a marketed spray dried formulation.Otero Espinar, Francisco JavierÁlvarez Fernández, LisardoUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20242024-01-0120242024-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/34496reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/344962026-06-15T12:47:27Z
dc.title.none.fl_str_mv Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
title Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
spellingShingle Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
Fradera Gelabert, Sara
320908 Preparación de medicamentos
320902 Composición de medicamentos
title_short Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
title_full Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
title_fullStr Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
title_full_unstemmed Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
title_sort Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
dc.creator.none.fl_str_mv Fradera Gelabert, Sara
author Fradera Gelabert, Sara
author_facet Fradera Gelabert, Sara
author_role author
dc.contributor.none.fl_str_mv Otero Espinar, Francisco Javier
Álvarez Fernández, Lisardo
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv 320908 Preparación de medicamentos
320902 Composición de medicamentos
topic 320908 Preparación de medicamentos
320902 Composición de medicamentos
description In the present thesis, it is demonstrated the potential of fluid bed top-spray technology as an alternative to spray drying for the production of amorphous solid dispersions (ASDs) intended for immediate drug release systems, i.e. tablets. Comparative analysis of ASDs physical properties, stability, and dissolution profiles obtained via both technologies were conducted. The effect of formulation variables, using fluid bed, was evaluated guided by a Quality by Design (QbD) approach. Finally, three ASD-based prototypes produced using fluid bed top-spray and different polymeric carriers (HPMCAS-MG and HPMCP HP-55) were developed followed by an in vivo pilot bioavailability study comparing their pharmacokinetic behaviour with a marketed spray dried formulation.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/34496
url http://hdl.handle.net/10347/34496
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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