Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

Producción Científica

Detalhes bibliográficos
Autores: Labrador Velandia, Sonia Cecilia, Alonso Alonso, María Luz, Álvarez Sánchez, Sara, González Zamora, Jorge, Pastor Jimeno, José Carlos, Fernández Bueno, Iván, Srivastava, Girish Kumar
Tipo de documento: artigo
Data de publicação:2016
País:España
Recursos:Universidad de Valladolid
Repositório:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/21595
Acesso em linha:https://doi.org/10.4252/wjsc.v8.i11.376
http://uvadoc.uva.es/handle/10324/21595
Access Level:Acceso aberto
Palavra-chave:Células madre
Retina
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spelling Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trialsLabrador Velandia, Sonia CeciliaAlonso Alonso, María LuzÁlvarez Sánchez, SaraGonzález Zamora, JorgePastor Jimeno, José CarlosFernández Bueno, IvánSrivastava, Girish KumarCélulas madreRetinaProducción CientíficaRetinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseasesJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13)Baishideng Publishing Group2016info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.4252/wjsc.v8.i11.376http://uvadoc.uva.es/handle/10324/21595reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttp://www.wjgnet.com/1948-0210/index.htminfo:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/215952026-06-13T12:44:47Z
dc.title.none.fl_str_mv Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
title Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
spellingShingle Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
Labrador Velandia, Sonia Cecilia
Células madre
Retina
title_short Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
title_full Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
title_fullStr Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
title_full_unstemmed Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
title_sort Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
dc.creator.none.fl_str_mv Labrador Velandia, Sonia Cecilia
Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernández Bueno, Iván
Srivastava, Girish Kumar
author Labrador Velandia, Sonia Cecilia
author_facet Labrador Velandia, Sonia Cecilia
Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernández Bueno, Iván
Srivastava, Girish Kumar
author_role author
author2 Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernández Bueno, Iván
Srivastava, Girish Kumar
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Células madre
Retina
topic Células madre
Retina
description Producción Científica
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.4252/wjsc.v8.i11.376
http://uvadoc.uva.es/handle/10324/21595
url https://doi.org/10.4252/wjsc.v8.i11.376
http://uvadoc.uva.es/handle/10324/21595
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.wjgnet.com/1948-0210/index.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
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