GNB3 C825T Polymorphism and elite athletic status: A replication study with two ethnic groups
We aimed to replicate the original findings by Eynon et al. showing an association between the T allele of the GNB3 C825T polymorphism and elite endurance athletic status, in larger cohorts and in other ethnicities. We compared allelic and genotypic frequencies of the GNB3 C825T polymorphism among n...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universidad Europea (UEM) |
| Repositorio: | ABACUS. Repositorio de Producción Científica |
| Idioma: | inglés |
| OAI Identifier: | oai:abacus.universidadeuropea.com:11268/614 |
| Acceso en línea: | http://hdl.handle.net/11268/614 |
| Access Level: | acceso abierto |
| Palabra clave: | Athletes* Polymorphism, Single Nucleotide* Ethnic Groups/*Genetics Heterotrimeric Gtp-Binding Proteins/*Genetics Athletic Performance Cohort Studies Female Genetic Association Studies Genetic Testing Genetics, Population Genotype Humans Israel Male Middle Aged Odds Ratio Phenotype Reproducibility of Results Spain Genética humana |
| Sumario: | We aimed to replicate the original findings by Eynon et al. showing an association between the T allele of the GNB3 C825T polymorphism and elite endurance athletic status, in larger cohorts and in other ethnicities. We compared allelic and genotypic frequencies of the GNB3 C825T polymorphism among non-athletic controls (N=340), elite endurance athletes (N=174), and power athletes (N=134). The population sample included participants from 2 different ethnic/geographic backgrounds (Israel and Spain). We observed no significant differences in genotypic and allelic frequencies between countries or groups (all P>0.1). The odds ratio (OR) of being an endurance athlete if the subject had a T allele was 0.841 (95%CI: 0.638-1.110) compared to the control group and 1.047 (95% CI: 0.751-1.461) compared to the power group. Our findings support the need to corroborate genotype: phenotype associations in the field of sports genetics with the largest possible population samples, including populations of different ethnic backgrounds. |
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