GNB3 C825T Polymorphism and elite athletic status: A replication study with two ethnic groups

We aimed to replicate the original findings by Eynon et al. showing an association between the T allele of the GNB3 C825T polymorphism and elite endurance athletic status, in larger cohorts and in other ethnicities. We compared allelic and genotypic frequencies of the GNB3 C825T polymorphism among n...

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Detalhes bibliográficos
Autores: Ruiz, Jonatan R., Eynon, Nir, Meckel, Yoav, Fiuza Luces, María del Carmen, Oliveira, José, Santiago Dorrego, Catalina, Gómez Gallego, Félix, Lucía Mulas, Alejandro
Tipo de documento: artigo
Data de publicação:2011
País:España
Recursos:Universidad Europea (UEM)
Repositório:ABACUS. Repositorio de Producción Científica
Idioma:inglês
OAI Identifier:oai:abacus.universidadeuropea.com:11268/614
Acesso em linha:http://hdl.handle.net/11268/614
Access Level:Acceso aberto
Palavra-chave:Athletes*
Polymorphism, Single Nucleotide*
Ethnic Groups/*Genetics
Heterotrimeric Gtp-Binding Proteins/*Genetics
Athletic Performance
Cohort Studies
Female
Genetic Association Studies
Genetic Testing
Genetics, Population
Genotype
Humans
Israel
Male
Middle Aged
Odds Ratio
Phenotype
Reproducibility of Results
Spain
Genética humana
Descrição
Resumo:We aimed to replicate the original findings by Eynon et al. showing an association between the T allele of the GNB3 C825T polymorphism and elite endurance athletic status, in larger cohorts and in other ethnicities. We compared allelic and genotypic frequencies of the GNB3 C825T polymorphism among non-athletic controls (N=340), elite endurance athletes (N=174), and power athletes (N=134). The population sample included participants from 2 different ethnic/geographic backgrounds (Israel and Spain). We observed no significant differences in genotypic and allelic frequencies between countries or groups (all P>0.1). The odds ratio (OR) of being an endurance athlete if the subject had a T allele was 0.841 (95%CI: 0.638-1.110) compared to the control group and 1.047 (95% CI: 0.751-1.461) compared to the power group. Our findings support the need to corroborate genotype: phenotype associations in the field of sports genetics with the largest possible population samples, including populations of different ethnic backgrounds.

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