Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller

OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controll...

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Autores: Pernas, Maria, Casado, Concepcion, Arcones, Carolina, Llano, Anuska, Sanchez-Merino, Victor, Mothe, Beatriz, Vicario, José L, Grau, Eulalia, Ruiz, Lidia, Sánchez, Jorge, Telenti, Amalio, Yuste-Herranz, Maria Eloisa, Brander, Christian, Lopez-Galindez, Luis Cecilio
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6828
Acceso en línea:http://hdl.handle.net/20.500.12105/6828
Access Level:acceso abierto
Palabra clave:Antiviral Agents
CD4-Positive T-Lymphocytes
Chemokines
Disease Progression
Genotype
HIV-1
Haplotypes
Humans
Immune System
Leukocytes, Mononuclear
Likelihood Functions
Male
Mutation
Polymorphism, Genetic
Recombinant Proteins
Time Factors
Viral Load
Virus Replication
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repository_id_str
spelling Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controllerPernas, MariaCasado, ConcepcionArcones, CarolinaLlano, AnuskaSanchez-Merino, VictorMothe, BeatrizVicario, José LGrau, EulaliaRuiz, LidiaSánchez, JorgeTelenti, AmalioYuste-Herranz, Maria EloisaBrander, ChristianLopez-Galindez, Luis CecilioAntiviral AgentsCD4-Positive T-LymphocytesChemokinesDisease ProgressionGenotypeHIV-1HaplotypesHumansImmune SystemLeukocytes, MononuclearLikelihood FunctionsMaleMutationPolymorphism, GeneticRecombinant ProteinsTime FactorsViral LoadVirus ReplicationOBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.Public Library of Science (PLOS)Ministerio de Economía y Competitividad (España)Fundación para la Investigación y la Prevención del Sida en EspañaNational Institutes of Health (Estados Unidos)Instituto de Salud Carlos III20182018-12-1220122012-02-2420122012-02-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6828reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES SAF-2007-61036 Not availableES SAF-2010-17226 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/68282026-06-12T12:43:37Z
dc.title.none.fl_str_mv Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
title Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
spellingShingle Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
Pernas, Maria
Antiviral Agents
CD4-Positive T-Lymphocytes
Chemokines
Disease Progression
Genotype
HIV-1
Haplotypes
Humans
Immune System
Leukocytes, Mononuclear
Likelihood Functions
Male
Mutation
Polymorphism, Genetic
Recombinant Proteins
Time Factors
Viral Load
Virus Replication
title_short Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
title_full Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
title_fullStr Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
title_full_unstemmed Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
title_sort Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
dc.creator.none.fl_str_mv Pernas, Maria
Casado, Concepcion
Arcones, Carolina
Llano, Anuska
Sanchez-Merino, Victor
Mothe, Beatriz
Vicario, José L
Grau, Eulalia
Ruiz, Lidia
Sánchez, Jorge
Telenti, Amalio
Yuste-Herranz, Maria Eloisa
Brander, Christian
Lopez-Galindez, Luis Cecilio
author Pernas, Maria
author_facet Pernas, Maria
Casado, Concepcion
Arcones, Carolina
Llano, Anuska
Sanchez-Merino, Victor
Mothe, Beatriz
Vicario, José L
Grau, Eulalia
Ruiz, Lidia
Sánchez, Jorge
Telenti, Amalio
Yuste-Herranz, Maria Eloisa
Brander, Christian
Lopez-Galindez, Luis Cecilio
author_role author
author2 Casado, Concepcion
Arcones, Carolina
Llano, Anuska
Sanchez-Merino, Victor
Mothe, Beatriz
Vicario, José L
Grau, Eulalia
Ruiz, Lidia
Sánchez, Jorge
Telenti, Amalio
Yuste-Herranz, Maria Eloisa
Brander, Christian
Lopez-Galindez, Luis Cecilio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Fundación para la Investigación y la Prevención del Sida en España
National Institutes of Health (Estados Unidos)
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Antiviral Agents
CD4-Positive T-Lymphocytes
Chemokines
Disease Progression
Genotype
HIV-1
Haplotypes
Humans
Immune System
Leukocytes, Mononuclear
Likelihood Functions
Male
Mutation
Polymorphism, Genetic
Recombinant Proteins
Time Factors
Viral Load
Virus Replication
topic Antiviral Agents
CD4-Positive T-Lymphocytes
Chemokines
Disease Progression
Genotype
HIV-1
Haplotypes
Humans
Immune System
Leukocytes, Mononuclear
Likelihood Functions
Male
Mutation
Polymorphism, Genetic
Recombinant Proteins
Time Factors
Viral Load
Virus Replication
description OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-02-24
2012
2012-02-24
2018
2018-12-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6828
url http://hdl.handle.net/20.500.12105/6828
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES SAF-2007-61036 Not available
ES SAF-2010-17226 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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