Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller

OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controll...

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Detalles Bibliográficos
Autores: Pernas, Maria, Casado, Concepcion, Arcones, Carolina, Llano, Anuska, Sanchez-Merino, Victor, Mothe, Beatriz, Vicario, José L, Grau, Eulalia, Ruiz, Lidia, Sánchez, Jorge, Telenti, Amalio, Yuste-Herranz, Maria Eloisa, Brander, Christian, Lopez-Galindez, Luis Cecilio
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6828
Acceso en línea:http://hdl.handle.net/20.500.12105/6828
Access Level:acceso abierto
Palabra clave:Antiviral Agents
CD4-Positive T-Lymphocytes
Chemokines
Disease Progression
Genotype
HIV-1
Haplotypes
Humans
Immune System
Leukocytes, Mononuclear
Likelihood Functions
Male
Mutation
Polymorphism, Genetic
Recombinant Proteins
Time Factors
Viral Load
Virus Replication
Descripción
Sumario:OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.

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