Mechanics-driven mechanobiological mechanisms of arterial tortuosity

[EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain po...

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Autores: Weiss, Dar, Cavinato, Cristina, Gray, Authia, Ramachandra, Abhay B., Avril, Stephane, Humphrey, Jay D., Latorre, Marcos|||0000-0003-4142-0207
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/191511
Acceso en línea:https://riunet.upv.es/handle/10251/191511
Access Level:acceso abierto
Palabra clave:Tortuosity
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
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spelling Mechanics-driven mechanobiological mechanisms of arterial tortuosityWeiss, DarCavinato, CristinaGray, AuthiaRamachandra, Abhay B.Avril, StephaneHumphrey, Jay D.Latorre, Marcos|||0000-0003-4142-0207Tortuosity03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades[EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain poorly understood but are widely appreciated to be largely biomechanical. Many previous studies suggested that tortuosity may arise via an elastic structural buckling instability, but the novel experimental-computational approach used here suggests that tortuosity arises from mechanosensitive, cell-mediated responses to local aberrations in the microstructural integrity of the arterial wall. In particular, computations informed by multimodality imaging show that aberrations in elastic fiber integrity, collagen alignment, and collagen turnover can lead to a progressive loss of structural stability that entrenches during the development of tortuosity. Interpreted in this way, microstructural defects or irregularities of the arterial wall initiate the condition and hypertension is a confounding factor.This work was supported by grants from the U.S. NIH (R01 HL105297, P01 HL134605, and U01 HL142518)American Association for the Advancement of ScienceDepartamento de Mecánica de los Medios Continuos y Teoría de EstructurasEscuela Técnica Superior de Ingeniería IndustrialCentro de Investigación e Innovación en BioingenieríaNational Institutes of Health, EEUURepositorio Institucional de la Universitat Politècnica de València Riunet20202020-12-04journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/191511reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 R01 HL105297 Mechanisms Underlying the Progression of Arterial Stiffness in HypertensionNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 P01 HL134605 Endothelial Mechanotransduction in Thoracic Aneurysm Formation and ProgressionNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 U01 HL142518 Multimodality imaging-driven multifidelity modeling of aortic dissectionopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1915112026-06-13T07:49:27Z
dc.title.none.fl_str_mv Mechanics-driven mechanobiological mechanisms of arterial tortuosity
title Mechanics-driven mechanobiological mechanisms of arterial tortuosity
spellingShingle Mechanics-driven mechanobiological mechanisms of arterial tortuosity
Weiss, Dar
Tortuosity
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
title_short Mechanics-driven mechanobiological mechanisms of arterial tortuosity
title_full Mechanics-driven mechanobiological mechanisms of arterial tortuosity
title_fullStr Mechanics-driven mechanobiological mechanisms of arterial tortuosity
title_full_unstemmed Mechanics-driven mechanobiological mechanisms of arterial tortuosity
title_sort Mechanics-driven mechanobiological mechanisms of arterial tortuosity
dc.creator.none.fl_str_mv Weiss, Dar
Cavinato, Cristina
Gray, Authia
Ramachandra, Abhay B.
Avril, Stephane
Humphrey, Jay D.
Latorre, Marcos|||0000-0003-4142-0207
author Weiss, Dar
author_facet Weiss, Dar
Cavinato, Cristina
Gray, Authia
Ramachandra, Abhay B.
Avril, Stephane
Humphrey, Jay D.
Latorre, Marcos|||0000-0003-4142-0207
author_role author
author2 Cavinato, Cristina
Gray, Authia
Ramachandra, Abhay B.
Avril, Stephane
Humphrey, Jay D.
Latorre, Marcos|||0000-0003-4142-0207
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Mecánica de los Medios Continuos y Teoría de Estructuras
Escuela Técnica Superior de Ingeniería Industrial
Centro de Investigación e Innovación en Bioingeniería
National Institutes of Health, EEUU
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Tortuosity
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
topic Tortuosity
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
description [EN] Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain poorly understood but are widely appreciated to be largely biomechanical. Many previous studies suggested that tortuosity may arise via an elastic structural buckling instability, but the novel experimental-computational approach used here suggests that tortuosity arises from mechanosensitive, cell-mediated responses to local aberrations in the microstructural integrity of the arterial wall. In particular, computations informed by multimodality imaging show that aberrations in elastic fiber integrity, collagen alignment, and collagen turnover can lead to a progressive loss of structural stability that entrenches during the development of tortuosity. Interpreted in this way, microstructural defects or irregularities of the arterial wall initiate the condition and hypertension is a confounding factor.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-12-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/191511
url https://riunet.upv.es/handle/10251/191511
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv National Institutes of Health, EEUU https://doi.org/10.13039/100000002 R01 HL105297 Mechanisms Underlying the Progression of Arterial Stiffness in Hypertension
National Institutes of Health, EEUU https://doi.org/10.13039/100000002 P01 HL134605 Endothelial Mechanotransduction in Thoracic Aneurysm Formation and Progression
National Institutes of Health, EEUU https://doi.org/10.13039/100000002 U01 HL142518 Multimodality imaging-driven multifidelity modeling of aortic dissection
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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