Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up

Santos García, Diego; Deus-Fonticoba, Teresa de; Cores Bartolomé, Carlos; Canfield, Héctor; Paz González, José Manuel; Martínez Miró, Cristina; Valdés Aymerich, Lorena; Suárez Castro, Ester; Jesús, Silvia; Aguilar, Miquel; Pastor, Pau; Planellás, Lluis L.; Cosgaya, Marina; García Caldentey, Juan; Caballol, Núria; Legarda, Inés; Hernández Vara, Jorge; Cabo López, Iria; López Manzanares, Lydia; González Aramburu, Isabel; Ávila Rivera, María A.; Catalán, María José; Nogueira, Víctor; Puente, Víctor; Dotor, Julio; Borrue, Carmen; Solano, Berta; Álvarez Saúco, María; Vela Desojo, Lydia; Escalante Arroyo, Sonia; Cubo Delgado, Esther; Carrillo Padilla, Francisco; Martínez Castrillo, Juan Carlos; Sánchez Alonso, Pilar; Alonso Losada, María Gema; López Ariztegui, Nuria; Gastón, Itziar; Kulisevsky Bojarsky, Jaume; Blázquez Estrada, Marta; Seijo, Manuel; Ruíz Martínez, Javier; Valero, Caridad; Kurtis, Mónica M.; Fabregues, Oriol de; González Ardura, Jessica; Alonso Redondo, Rubén; Ordás Bandera, Carlos Manuel; López Díaz, Luis M.; McAfee, Darrian; Martínez Martín, Pablo; Mir, Pablo; COPPADIS Study Group

Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up

Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) t...

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Autores:	Santos García, Diego, Deus-Fonticoba, Teresa de, Cores Bartolomé, Carlos, Canfield, Héctor, Paz González, José Manuel, Martínez Miró, Cristina, Valdés Aymerich, Lorena, Suárez Castro, Ester, Jesús, Silvia, Aguilar, Miquel, Pastor, Pau, Planellás, Lluis L., Cosgaya, Marina, García Caldentey, Juan, Caballol, Núria, Legarda, Inés, Hernández Vara, Jorge, Cabo López, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, María A., Catalán, María José, Nogueira, Víctor, Puente, Víctor, Dotor, Julio, Borrue, Carmen, Solano, Berta, Álvarez Saúco, María, Vela Desojo, Lydia, Escalante Arroyo, Sonia, Cubo Delgado, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan Carlos, Sánchez Alonso, Pilar, Alonso Losada, María Gema, López Ariztegui, Nuria, Gastón, Itziar, Kulisevsky Bojarsky, Jaume, Blázquez Estrada, Marta, Seijo, Manuel, Ruíz Martínez, Javier, Valero, Caridad, Kurtis, Mónica M., Fabregues, Oriol de, González Ardura, Jessica, Alonso Redondo, Rubén, Ordás Bandera, Carlos Manuel, López Díaz, Luis M., McAfee, Darrian, Martínez Martín, Pablo, Mir, Pablo, COPPADIS Study Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Burgos (UBU)
Repositorio:	Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:	oai:riubu.ubu.es:10259/8805
Acceso en línea:	http://hdl.handle.net/10259/8805
Access Level:	acceso abierto
Palabra clave:	Mood Non-motor symptoms Parkinson’s disease Progression Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology

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spelling	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-UpSantos García, DiegoDeus-Fonticoba, Teresa deCores Bartolomé, CarlosCanfield, HéctorPaz González, José ManuelMartínez Miró, CristinaValdés Aymerich, LorenaSuárez Castro, EsterJesús, SilviaAguilar, MiquelPastor, PauPlanellás, Lluis L.Cosgaya, MarinaGarcía Caldentey, JuanCaballol, NúriaLegarda, InésHernández Vara, JorgeCabo López, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, María A.Catalán, María JoséNogueira, VíctorPuente, VíctorDotor, JulioBorrue, CarmenSolano, BertaÁlvarez Saúco, MaríaVela Desojo, LydiaEscalante Arroyo, SoniaCubo Delgado, EstherCarrillo Padilla, FranciscoMartínez Castrillo, Juan CarlosSánchez Alonso, PilarAlonso Losada, María GemaLópez Ariztegui, NuriaGastón, ItziarKulisevsky Bojarsky, JaumeBlázquez Estrada, MartaSeijo, ManuelRuíz Martínez, JavierValero, CaridadKurtis, Mónica M.Fabregues, Oriol deGonzález Ardura, JessicaAlonso Redondo, RubénOrdás Bandera, Carlos ManuelLópez Díaz, Luis M.McAfee, DarrianMartínez Martín, PabloMir, PabloCOPPADIS Study GroupMoodNon-motor symptomsParkinson’s diseaseProgressionQuality of lifeSistema nervioso-EnfermedadesMedicinaNeurologíaNervous system-DiseasesMedicineNeurologyBackground and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.MDPI202420242021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/8805reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésJournal of Personalized Medicine. 2021, V. 11, n. 7, 626https://doi.org/10.3390/jpm11070626Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/88052026-05-28T07:56:11Z
dc.title.none.fl_str_mv	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
title	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
spellingShingle	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up Santos García, Diego Mood Non-motor symptoms Parkinson’s disease Progression Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
title_short	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
title_full	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
title_fullStr	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
title_full_unstemmed	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
title_sort	Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
dc.creator.none.fl_str_mv	Santos García, Diego Deus-Fonticoba, Teresa de Cores Bartolomé, Carlos Canfield, Héctor Paz González, José Manuel Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez Castro, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellás, Lluis L. Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Inés Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José Nogueira, Víctor Puente, Víctor Dotor, Julio Borrue, Carmen Solano, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Alonso Redondo, Rubén Ordás Bandera, Carlos Manuel López Díaz, Luis M. McAfee, Darrian Martínez Martín, Pablo Mir, Pablo COPPADIS Study Group
author	Santos García, Diego
author_facet	Santos García, Diego Deus-Fonticoba, Teresa de Cores Bartolomé, Carlos Canfield, Héctor Paz González, José Manuel Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez Castro, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellás, Lluis L. Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Inés Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José Nogueira, Víctor Puente, Víctor Dotor, Julio Borrue, Carmen Solano, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Alonso Redondo, Rubén Ordás Bandera, Carlos Manuel López Díaz, Luis M. McAfee, Darrian Martínez Martín, Pablo Mir, Pablo COPPADIS Study Group
author_role	author
author2	Deus-Fonticoba, Teresa de Cores Bartolomé, Carlos Canfield, Héctor Paz González, José Manuel Martínez Miró, Cristina Valdés Aymerich, Lorena Suárez Castro, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellás, Lluis L. Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Inés Hernández Vara, Jorge Cabo López, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, María A. Catalán, María José Nogueira, Víctor Puente, Víctor Dotor, Julio Borrue, Carmen Solano, Berta Álvarez Saúco, María Vela Desojo, Lydia Escalante Arroyo, Sonia Cubo Delgado, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Carlos Sánchez Alonso, Pilar Alonso Losada, María Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky Bojarsky, Jaume Blázquez Estrada, Marta Seijo, Manuel Ruíz Martínez, Javier Valero, Caridad Kurtis, Mónica M. Fabregues, Oriol de González Ardura, Jessica Alonso Redondo, Rubén Ordás Bandera, Carlos Manuel López Díaz, Luis M. McAfee, Darrian Martínez Martín, Pablo Mir, Pablo COPPADIS Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Mood Non-motor symptoms Parkinson’s disease Progression Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
topic	Mood Non-motor symptoms Parkinson’s disease Progression Quality of life Sistema nervioso-Enfermedades Medicina Neurología Nervous system-Diseases Medicine Neurology
description	Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.
publishDate	2021
dc.date.none.fl_str_mv	2021 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10259/8805
url	http://hdl.handle.net/10259/8805
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Journal of Personalized Medicine. 2021, V. 11, n. 7, 626 https://doi.org/10.3390/jpm11070626
dc.rights.none.fl_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU) instname:Universidad de Burgos (UBU)
instname_str	Universidad de Burgos (UBU)
reponame_str	Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection	Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,301603

Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up

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