Polysaccharide-based aerogel microspheres for oral drug delivery

Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres fro...

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Detalles Bibliográficos
Autores: García González, Carlos A., Jin, Ming, Gerth, J., Álvarez Lorenzo, Carmen, Smirnova, I.
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/12302
Acceso en línea:http://hdl.handle.net/10347/12302
Access Level:acceso abierto
Palabra clave:Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
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spelling Polysaccharide-based aerogel microspheres for oral drug deliveryGarcía González, Carlos A.Jin, MingGerth, J.Álvarez Lorenzo, CarmenSmirnova, I.Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materialesPolysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10−3 and 1.7 × 10−3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher–Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min−1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.ElsevierUniversidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica20152015-03-0620152015-03-06journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/12302reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/123022026-06-15T12:47:27Z
dc.title.none.fl_str_mv Polysaccharide-based aerogel microspheres for oral drug delivery
title Polysaccharide-based aerogel microspheres for oral drug delivery
spellingShingle Polysaccharide-based aerogel microspheres for oral drug delivery
García González, Carlos A.
Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
title_short Polysaccharide-based aerogel microspheres for oral drug delivery
title_full Polysaccharide-based aerogel microspheres for oral drug delivery
title_fullStr Polysaccharide-based aerogel microspheres for oral drug delivery
title_full_unstemmed Polysaccharide-based aerogel microspheres for oral drug delivery
title_sort Polysaccharide-based aerogel microspheres for oral drug delivery
dc.creator.none.fl_str_mv García González, Carlos A.
Jin, Ming
Gerth, J.
Álvarez Lorenzo, Carmen
Smirnova, I.
author García González, Carlos A.
author_facet García González, Carlos A.
Jin, Ming
Gerth, J.
Álvarez Lorenzo, Carmen
Smirnova, I.
author_role author
author2 Jin, Ming
Gerth, J.
Álvarez Lorenzo, Carmen
Smirnova, I.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica
dc.subject.none.fl_str_mv Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
topic Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
description Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10−3 and 1.7 × 10−3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher–Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min−1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-03-06
2015
2015-03-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/12302
url http://hdl.handle.net/10347/12302
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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