Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI

BACKGROUNDCortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS.METHODSWe included 195 adults with DS, 63 with symptomatic sporadic Alzhei...

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Detalhes bibliográficos
Autores: Aranha, MR, Montal, V, van den Brink, H, Pegueroles, J, Carmona-Iragui, M, Videla, L, Blesa, LM, Benejam, B, Arranz, J, Valldeneu, S, Barroeta, I, Fernández, S, Ribas, L, Alcolea, D, González-Ortiz, S, Bargalló, N, Biessels, GJ, Blesa, R, Lleó, A, Coutinho, AM, Leite, CC, Bejanin, A, Fortea, J
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p17656
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17656
http://ddd.uab.cat/record/306327
Access Level:acceso abierto
Palavra-chave:Alzheimer's disease
cerebral amyloid angiopathy
cerebral microbleeds
cortical microinfarcts
Down syndrome
magnetic resonance imaging
neuroimaging
small vessel diseases
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spelling Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRIAranha, MRMontal, Vvan den Brink, HPegueroles, JCarmona-Iragui, MVidela, LBlesa, LMBenejam, BArranz, JValldeneu, SBarroeta, IFernández, SRibas, LAlcolea, DGonzález-Ortiz, SBargalló, NBiessels, GJBlesa, RLleó, ACoutinho, AMLeite, CCBejanin, AFortea, JAlzheimer's diseasecerebral amyloid angiopathycerebral microbleedscortical microinfarctsDown syndromemagnetic resonance imagingneuroimagingsmall vessel diseasesBACKGROUNDCortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS.METHODSWe included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS.RESULTSCMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions.DISCUSSIONIn DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.Highlights This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.WILEY2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17656http://ddd.uab.cat/record/306327ALZHEIMERS & DEMENTIAISSN: 15525260ISSNe: 15525279reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p176562026-06-14T12:41:47Z
dc.title.none.fl_str_mv Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
title Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
spellingShingle Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
Aranha, MR
Alzheimer's disease
cerebral amyloid angiopathy
cerebral microbleeds
cortical microinfarcts
Down syndrome
magnetic resonance imaging
neuroimaging
small vessel diseases
title_short Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
title_full Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
title_fullStr Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
title_full_unstemmed Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
title_sort Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
dc.creator.none.fl_str_mv Aranha, MR
Montal, V
van den Brink, H
Pegueroles, J
Carmona-Iragui, M
Videla, L
Blesa, LM
Benejam, B
Arranz, J
Valldeneu, S
Barroeta, I
Fernández, S
Ribas, L
Alcolea, D
González-Ortiz, S
Bargalló, N
Biessels, GJ
Blesa, R
Lleó, A
Coutinho, AM
Leite, CC
Bejanin, A
Fortea, J
author Aranha, MR
author_facet Aranha, MR
Montal, V
van den Brink, H
Pegueroles, J
Carmona-Iragui, M
Videla, L
Blesa, LM
Benejam, B
Arranz, J
Valldeneu, S
Barroeta, I
Fernández, S
Ribas, L
Alcolea, D
González-Ortiz, S
Bargalló, N
Biessels, GJ
Blesa, R
Lleó, A
Coutinho, AM
Leite, CC
Bejanin, A
Fortea, J
author_role author
author2 Montal, V
van den Brink, H
Pegueroles, J
Carmona-Iragui, M
Videla, L
Blesa, LM
Benejam, B
Arranz, J
Valldeneu, S
Barroeta, I
Fernández, S
Ribas, L
Alcolea, D
González-Ortiz, S
Bargalló, N
Biessels, GJ
Blesa, R
Lleó, A
Coutinho, AM
Leite, CC
Bejanin, A
Fortea, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer's disease
cerebral amyloid angiopathy
cerebral microbleeds
cortical microinfarcts
Down syndrome
magnetic resonance imaging
neuroimaging
small vessel diseases
topic Alzheimer's disease
cerebral amyloid angiopathy
cerebral microbleeds
cortical microinfarcts
Down syndrome
magnetic resonance imaging
neuroimaging
small vessel diseases
description BACKGROUNDCortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS.METHODSWe included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS.RESULTSCMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions.DISCUSSIONIn DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.Highlights This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17656
http://ddd.uab.cat/record/306327
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17656
http://ddd.uab.cat/record/306327
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ALZHEIMERS & DEMENTIA
ISSN: 15525260
ISSNe: 15525279
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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