Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study

Vitelli Storelli, Facundo; Molina de la Torre, Antonio José; Zamora-Ros, Raul; Fernández Villa, Tania; Roussou, Vasiliki; Romaguera, Dora; Aragonès Sanz, Núria; Obón Santacana, Mireia; Guevara, Marcela; Gómez Acebo, Inés; Fernández Tardón, Guillermo; Molina Barceló, Ana; Olmedo Requena, Rocío; Capelo Álvarez, Rocío; Chirlaque, María Dolores; Pérez Gómez, Beatriz; Moreno Aguado, Víctor; Castilla, Jesús; Rubín García, María; Pollán, Marina; Kogevinas, Manolis; Barrio Lera, Juan Pablo; Martín Sánchez, Vicente

Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study

Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be...

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Autores:	Vitelli Storelli, Facundo, Molina de la Torre, Antonio José, Zamora-Ros, Raul, Fernández Villa, Tania, Roussou, Vasiliki, Romaguera, Dora, Aragonès Sanz, Núria, Obón Santacana, Mireia, Guevara, Marcela, Gómez Acebo, Inés, Fernández Tardón, Guillermo, Molina Barceló, Ana, Olmedo Requena, Rocío, Capelo Álvarez, Rocío, Chirlaque, María Dolores, Pérez Gómez, Beatriz, Moreno Aguado, Víctor, Castilla, Jesús, Rubín García, María, Pollán, Marina, Kogevinas, Manolis, Barrio Lera, Juan Pablo, Martín Sánchez, Vicente
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2019
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/171674
Acceso en línea:	https://hdl.handle.net/2445/171674
Access Level:	acceso abierto
Palabra clave:	Dieta Flavonoides Farmacologia Càncer d'estómac Diet Flavonoids Pharmacology Stomach cancer

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spelling	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain StudyVitelli Storelli, FacundoMolina de la Torre, Antonio JoséZamora-Ros, RaulFernández Villa, TaniaRoussou, VasilikiRomaguera, DoraAragonès Sanz, NúriaObón Santacana, MireiaGuevara, MarcelaGómez Acebo, InésFernández Tardón, GuillermoMolina Barceló, AnaOlmedo Requena, RocíoCapelo Álvarez, RocíoChirlaque, María DoloresPérez Gómez, BeatrizMoreno Aguado, VíctorCastilla, JesúsRubín García, MaríaPollán, MarinaKogevinas, ManolisBarrio Lera, Juan PabloMartín Sánchez, VicenteDietaFlavonoidesFarmacologiaCàncer d'estómacDietFlavonoidsPharmacologyStomach cancerSeveral epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.MDPI2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/171674Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu11050967Nutrients, 2019, vol. 11, num. 5, p. 967https://doi.org/10.3390/nu11050967cc-by (c) Vitelli Storelli, Facundo et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1716742026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
title	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
spellingShingle	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study Vitelli Storelli, Facundo Dieta Flavonoides Farmacologia Càncer d'estómac Diet Flavonoids Pharmacology Stomach cancer
title_short	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
title_full	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
title_fullStr	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
title_full_unstemmed	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
title_sort	Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study
dc.creator.none.fl_str_mv	Vitelli Storelli, Facundo Molina de la Torre, Antonio José Zamora-Ros, Raul Fernández Villa, Tania Roussou, Vasiliki Romaguera, Dora Aragonès Sanz, Núria Obón Santacana, Mireia Guevara, Marcela Gómez Acebo, Inés Fernández Tardón, Guillermo Molina Barceló, Ana Olmedo Requena, Rocío Capelo Álvarez, Rocío Chirlaque, María Dolores Pérez Gómez, Beatriz Moreno Aguado, Víctor Castilla, Jesús Rubín García, María Pollán, Marina Kogevinas, Manolis Barrio Lera, Juan Pablo Martín Sánchez, Vicente
author	Vitelli Storelli, Facundo
author_facet	Vitelli Storelli, Facundo Molina de la Torre, Antonio José Zamora-Ros, Raul Fernández Villa, Tania Roussou, Vasiliki Romaguera, Dora Aragonès Sanz, Núria Obón Santacana, Mireia Guevara, Marcela Gómez Acebo, Inés Fernández Tardón, Guillermo Molina Barceló, Ana Olmedo Requena, Rocío Capelo Álvarez, Rocío Chirlaque, María Dolores Pérez Gómez, Beatriz Moreno Aguado, Víctor Castilla, Jesús Rubín García, María Pollán, Marina Kogevinas, Manolis Barrio Lera, Juan Pablo Martín Sánchez, Vicente
author_role	author
author2	Molina de la Torre, Antonio José Zamora-Ros, Raul Fernández Villa, Tania Roussou, Vasiliki Romaguera, Dora Aragonès Sanz, Núria Obón Santacana, Mireia Guevara, Marcela Gómez Acebo, Inés Fernández Tardón, Guillermo Molina Barceló, Ana Olmedo Requena, Rocío Capelo Álvarez, Rocío Chirlaque, María Dolores Pérez Gómez, Beatriz Moreno Aguado, Víctor Castilla, Jesús Rubín García, María Pollán, Marina Kogevinas, Manolis Barrio Lera, Juan Pablo Martín Sánchez, Vicente
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Dieta Flavonoides Farmacologia Càncer d'estómac Diet Flavonoids Pharmacology Stomach cancer
topic	Dieta Flavonoides Farmacologia Càncer d'estómac Diet Flavonoids Pharmacology Stomach cancer
description	Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.
publishDate	2019
dc.date.none.fl_str_mv	2019 2020 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/171674
url	https://hdl.handle.net/2445/171674
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/nu11050967 Nutrients, 2019, vol. 11, num. 5, p. 967 https://doi.org/10.3390/nu11050967
dc.rights.none.fl_str_mv	cc-by (c) Vitelli Storelli, Facundo et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Vitelli Storelli, Facundo et al., 2019 http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	15 p. application/pdf application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study

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