Flavonoids and the risk of gastric cancer: an exploratory case-control study in the MCC-Spain Study

Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be...

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Detalles Bibliográficos
Autores: Vitelli Storelli, Facundo, Molina de la Torre, Antonio José, Zamora-Ros, Raul, Fernández Villa, Tania, Roussou, Vasiliki, Romaguera, Dora, Aragonès Sanz, Núria, Obón Santacana, Mireia, Guevara, Marcela, Gómez Acebo, Inés, Fernández Tardón, Guillermo, Molina Barceló, Ana, Olmedo Requena, Rocío, Capelo Álvarez, Rocío, Chirlaque, María Dolores, Pérez Gómez, Beatriz, Moreno Aguado, Víctor, Castilla, Jesús, Rubín García, María, Pollán, Marina, Kogevinas, Manolis, Barrio Lera, Juan Pablo, Martín Sánchez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171674
Acceso en línea:https://hdl.handle.net/2445/171674
Access Level:acceso abierto
Palabra clave:Dieta
Flavonoides
Farmacologia
Càncer d'estómac
Diet
Flavonoids
Pharmacology
Stomach cancer
Descripción
Sumario:Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.

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