PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing

Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulat...

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Autores: Hernández Rivera, Gabriela, Váldez, Hugo A., Arango-Ospina, Marcela, Delgado, Juan Francisco, Aguilar-Rabiela, Arturo E., Gorgojo, Juan Pablo, Zhang, Huijun, Beltrán, Ana M., Boccaccini, Aldo R., Sánchez, Mirna Lorena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/163534
Acceso en línea:https://hdl.handle.net/11441/163534
https://doi.org/10.1016/j.jddst.2024.106235
Access Level:acceso abierto
Palabra clave:Hydrogels
Astaxanthin
Bioactive glass
Wound healing
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spelling PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healingHernández Rivera, GabrielaVáldez, Hugo A.Arango-Ospina, MarcelaDelgado, Juan FranciscoAguilar-Rabiela, Arturo E.Gorgojo, Juan PabloZhang, HuijunBeltrán, Ana M.Boccaccini, Aldo R.Sánchez, Mirna LorenaHydrogelsAstaxanthinBioactive glassWound healingAstaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.CITIUS, central services of the Universidad de Sevilla (Spain)ElsevierIngeniería y Ciencia de los Materiales y del TransporteTEP123: Metalurgia e Ingeniería de los Materiales2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/163534https://doi.org/10.1016/j.jddst.2024.106235reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)Ingléshttps://www.sciencedirect.com/science/article/pii/S1773224724009043info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1635342026-06-17T12:51:07Z
dc.title.none.fl_str_mv PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
spellingShingle PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
Hernández Rivera, Gabriela
Hydrogels
Astaxanthin
Bioactive glass
Wound healing
title_short PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_full PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_fullStr PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_full_unstemmed PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_sort PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
dc.creator.none.fl_str_mv Hernández Rivera, Gabriela
Váldez, Hugo A.
Arango-Ospina, Marcela
Delgado, Juan Francisco
Aguilar-Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sánchez, Mirna Lorena
author Hernández Rivera, Gabriela
author_facet Hernández Rivera, Gabriela
Váldez, Hugo A.
Arango-Ospina, Marcela
Delgado, Juan Francisco
Aguilar-Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sánchez, Mirna Lorena
author_role author
author2 Váldez, Hugo A.
Arango-Ospina, Marcela
Delgado, Juan Francisco
Aguilar-Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sánchez, Mirna Lorena
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería y Ciencia de los Materiales y del Transporte
TEP123: Metalurgia e Ingeniería de los Materiales
dc.subject.none.fl_str_mv Hydrogels
Astaxanthin
Bioactive glass
Wound healing
topic Hydrogels
Astaxanthin
Bioactive glass
Wound healing
description Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/163534
https://doi.org/10.1016/j.jddst.2024.106235
url https://hdl.handle.net/11441/163534
https://doi.org/10.1016/j.jddst.2024.106235
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1773224724009043
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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