Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study

Exposure to secondhand tobacco smoke (SHS) is a worldwide public health problem and children are a particularly vulnerable population due to their anatomical, physiological, and behavioral characteristics. Cotinine concentrations in saliva, blood, and hair have become the most widely used biomarkers...

Descripción completa

Detalles Bibliográficos
Autor: Mouriño Castro, Nerea
Tipo de recurso: tesis doctoral
Fecha de publicación:2022
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/29931
Acceso en línea:http://hdl.handle.net/10347/29931
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3202 Epidemologia
Materias::Investigación::32 Ciencias médicas::3212 Salud pública
id ES_e1c319ad5a2aa11470bed8a84d2bf396
oai_identifier_str oai:minerva.usc.gal:10347/29931
network_acronym_str ES
network_name_str España
repository_id_str
spelling Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort studyMouriño Castro, NereaMaterias::Investigación::32 Ciencias médicas::3202 EpidemologiaMaterias::Investigación::32 Ciencias médicas::3212 Salud públicaExposure to secondhand tobacco smoke (SHS) is a worldwide public health problem and children are a particularly vulnerable population due to their anatomical, physiological, and behavioral characteristics. Cotinine concentrations in saliva, blood, and hair have become the most widely used biomarkers of SHS in children. Currently, there is no consensus regarding the optimal cut-point for the classification of SHS exposure among young children. Indeed, the systematic review conducted as part of this thesis shows that serum cotinine cut-points have varied remarkably since 1985 and across the countries; the most recently used cut-point to assess SHS exposure in US children has been 0.015 ng/mL, which derives from the assay limit of detection (LOD) used by the National Health and Nutrition Examination Survey (NHANES). Considering that cotinine metabolism and clearance may vary by age, and that childrens physiology is quite different within the 0-5 years old age range, age-specific cut-points could be useful to accurately classify nonsmoking children as exposed or unexposed to SHS in a standardized manner. This thesis includes the first study estimating age-specific cut-points to classify SHS exposure among children under 5 years old. Interestingly, when applying these serum cotinine cut-points, compared to the assay LOD derived cut-point, results showed that prevalence of childrens SHS exposure declined at all ages, and that concordance between mother-reported SHS exposure and childrens serum cotinine improved considerably.Pérez Ríos, MónicaBraun, Joseph M.Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20222022-01-0120222022-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/29931reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/299312026-06-15T12:47:27Z
dc.title.none.fl_str_mv Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
title Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
spellingShingle Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
Mouriño Castro, Nerea
Materias::Investigación::32 Ciencias médicas::3202 Epidemologia
Materias::Investigación::32 Ciencias médicas::3212 Salud pública
title_short Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
title_full Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
title_fullStr Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
title_full_unstemmed Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
title_sort Relation of exposure to secondhand tobacco smoke during pregnancy and early childhood with adolescents body composition and cardiometabolic health: a cohort study
dc.creator.none.fl_str_mv Mouriño Castro, Nerea
author Mouriño Castro, Nerea
author_facet Mouriño Castro, Nerea
author_role author
dc.contributor.none.fl_str_mv Pérez Ríos, Mónica
Braun, Joseph M.
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3202 Epidemologia
Materias::Investigación::32 Ciencias médicas::3212 Salud pública
topic Materias::Investigación::32 Ciencias médicas::3202 Epidemologia
Materias::Investigación::32 Ciencias médicas::3212 Salud pública
description Exposure to secondhand tobacco smoke (SHS) is a worldwide public health problem and children are a particularly vulnerable population due to their anatomical, physiological, and behavioral characteristics. Cotinine concentrations in saliva, blood, and hair have become the most widely used biomarkers of SHS in children. Currently, there is no consensus regarding the optimal cut-point for the classification of SHS exposure among young children. Indeed, the systematic review conducted as part of this thesis shows that serum cotinine cut-points have varied remarkably since 1985 and across the countries; the most recently used cut-point to assess SHS exposure in US children has been 0.015 ng/mL, which derives from the assay limit of detection (LOD) used by the National Health and Nutrition Examination Survey (NHANES). Considering that cotinine metabolism and clearance may vary by age, and that childrens physiology is quite different within the 0-5 years old age range, age-specific cut-points could be useful to accurately classify nonsmoking children as exposed or unexposed to SHS in a standardized manner. This thesis includes the first study estimating age-specific cut-points to classify SHS exposure among children under 5 years old. Interestingly, when applying these serum cotinine cut-points, compared to the assay LOD derived cut-point, results showed that prevalence of childrens SHS exposure declined at all ages, and that concordance between mother-reported SHS exposure and childrens serum cotinine improved considerably.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/29931
url http://hdl.handle.net/10347/29931
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422322682691584
score 15,811543

Similares en LA Referencia