Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participant...

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Autores: Navarrete-Muñoz, Eva-María, Fitó Colomer, Montserrat, Castañer, Olga, Zomeño Fajardo, María Dolores, Goday Arnó, Albert, García de la Hera, Manuela
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48455
Acceso en línea:http://hdl.handle.net/10230/48455
http://dx.doi.org/10.1007/s00394-020-02364-4
Access Level:acceso abierto
Palabra clave:Cardiometabolic risk
Cholesterol
Diabetes
Folate
Metabolic syndrome score
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spelling Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional studyNavarrete-Muñoz, Eva-MaríaFitó Colomer, MontserratCastañer, OlgaZomeño Fajardo, María DoloresGoday Arnó, AlbertGarcía de la Hera, ManuelaCardiometabolic riskCholesterolDiabetesFolateMetabolic syndrome scorePurpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.Springer202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48455http://dx.doi.org/10.1007/s00394-020-02364-4reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEur J Nutr. 2021;60(2):1125-36© Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00394-020-02364-4.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/484552026-06-12T07:21:37Z
dc.title.none.fl_str_mv Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
title Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
spellingShingle Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
Navarrete-Muñoz, Eva-María
Cardiometabolic risk
Cholesterol
Diabetes
Folate
Metabolic syndrome score
title_short Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
title_full Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
title_fullStr Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
title_full_unstemmed Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
title_sort Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
dc.creator.none.fl_str_mv Navarrete-Muñoz, Eva-María
Fitó Colomer, Montserrat
Castañer, Olga
Zomeño Fajardo, María Dolores
Goday Arnó, Albert
García de la Hera, Manuela
author Navarrete-Muñoz, Eva-María
author_facet Navarrete-Muñoz, Eva-María
Fitó Colomer, Montserrat
Castañer, Olga
Zomeño Fajardo, María Dolores
Goday Arnó, Albert
García de la Hera, Manuela
author_role author
author2 Fitó Colomer, Montserrat
Castañer, Olga
Zomeño Fajardo, María Dolores
Goday Arnó, Albert
García de la Hera, Manuela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cardiometabolic risk
Cholesterol
Diabetes
Folate
Metabolic syndrome score
topic Cardiometabolic risk
Cholesterol
Diabetes
Folate
Metabolic syndrome score
description Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48455
http://dx.doi.org/10.1007/s00394-020-02364-4
url http://hdl.handle.net/10230/48455
http://dx.doi.org/10.1007/s00394-020-02364-4
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Eur J Nutr. 2021;60(2):1125-36
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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