Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

Purpose We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods A cross-sectional analysis with 6633 with overweight/obesity participants...

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Detalles Bibliográficos
Autores: Navarrete-Muñoz EM, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, de Cos Blanco AI, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castañer O, Colom A, Compañ-Gabucio L, Lete IS, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Sarasa I, Gámez JM, Garcia-Rios JMA, Martín-Pelaez S, Ruiz-Canela M, Díaz-López A, Martinez-Lacruz R, Zomeño MD, Rayó E, Sellés CG, Canudas S, Goday A, García-de-la-Hera M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8601
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/8601
Access Level:acceso abierto
Palabra clave:Folate
Cardiometabolic risk
Metabolic syndrome score
Diabetes
Cholesterol
Descripción
Sumario:Purpose We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (beta for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (beta = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (beta = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.

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