Sex differences in neural projections of fear memory processing in mice and humans

It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory cons...

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Detalles Bibliográficos
Autores: Florido Torres, Antonio Luis, Velasco, Eric R., Romero, Leire R., Acharya, Neha, Marin Blasco, Ignacio J., Nabás, Jaime F., Pérez-Caballero, Laura, Rivero, Guadalupe, Olabarrieta, Estíbaliz, Nuñez-delMoral, Amaia, González-Parra, Jose Antonio, Porta-Casteràs, Daniel, Cano, Marta, Steward, Trevor, Antony, Monica S., Cardoner, Narcís, Torrubia, Rafael, Jackson, Alexander C., Fullana Rivas, Miguel Ángel, Andero, Raül
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/70939
Acceso en línea:http://hdl.handle.net/10230/70939
http://dx.doi.org/10.1126/sciadv.adk3365
Access Level:acceso abierto
Palabra clave:Circuit neuronal
Descripción
Sumario:It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory consolidation in male mice but not females. Optogenetic excitation of CeM-Tac2 fibers in the BNSTpl exhibited enhanced inhibitory postsynaptic currents in males compared to females. In vivo calcium imaging analysis revealed a sex-dimorphic fear memory engram in the BNSTpl. Furthermore, in humans, the single-nucleotide polymorphism (SNP) in the Tac2 receptor (rs2765) (TAC3R) decreased CeM-BNST connectivity in a fear task, impaired fear memory consolidation, and increased the expression of the TAC3R mRNA in AA-carrier men but not in women. These sex differences in critical neuronal circuits underlying fear memory formation may be relevant to human neuropsychiatric disorders with fear memory alterations such as posttraumatic stress disorder.

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