Sex differences in neural projections of fear memory processing in mice and humans

It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory cons...

ver descrição completa

Detalhes bibliográficos
Autores: Florido Torres, Antonio Luis|||0000-0001-6184-0706, Velasco García, Eric Raúl|||0000-0002-8778-5618, Romero, Leire R., Acharya, Neha|||0000-0002-1024-3351, Marin Blasco, Ignacio Javier|||0000-0001-5096-2871, Fabregat Nabás, Jaime|||0000-0002-5040-0913, Perez-Caballero, Laura|||0000-0002-2315-2213, Rivero, Guadalupe|||0000-0002-2537-4047, Olabarrieta, Estibaliz|||0000-0001-7842-3298, Nuñez-delMoral, Amaia|||0000-0002-1749-7055, González-Parra, Jose A., Porta-Casteràs, Daniel|||0000-0002-3921-3607, Cano, Marta|||0000-0003-0675-9483, Steward, Trevor|||0000-0003-3116-8175, Antony, Monica S., Cardoner, Narcís|||0000-0001-9633-0888, Torrúbia, Rafael|||0000-0002-6826-6572, Jackson, Alexander|||0000-0001-7489-3946, Fullana, Miguel|||0000-0003-3863-5223, Andero Galí, Raül|||0000-0003-3641-8903
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308081
Acesso em linha:https://ddd.uab.cat/record/308081
https://dx.doi.org/urn:doi:10.1126/sciadv.adk3365
Access Level:acceso abierto
Palavra-chave:'current
Brain areas
Calcium imaging
Imaging analysis
In-vivo
Male mouse
Memory consolidation
Neuronal connectivity
Optogenetics
Sex difference
Adult
Animals
Fear
Female
Humans
Male
Memory
Mice
Polymorphism, Single Nucleotide
Sex Characteristics
Descrição
Resumo:It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory consolidation in male mice but not females. Optogenetic excitation of CeM-Tac2 fibers in the BNSTpl exhibited enhanced inhibitory postsynaptic currents in males compared to females. In vivo calcium imaging analysis revealed a sex-dimorphic fear memory engram in the BNSTpl. Furthermore, in humans, the single-nucleotide polymorphism (SNP) in the Tac2 receptor (rs2765) (TAC3R) decreased CeM-BNST connectivity in a fear task, impaired fear memory consolidation, and increased the expression of the TAC3R mRNA in AA-carrier men but not in women. These sex differences in critical neuronal circuits underlying fear memory formation may be relevant to human neuropsychiatric disorders with fear memory alterations such as posttraumatic stress disorder.

Registos relacionados