Myocardin-dependent Kv1.5 channel expression prevents phenotypic modulation of human vessels in organ culture

[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1.3 functional expression is relevant for PM in sev...

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Detalles Bibliográficos
Autores: Arévalo-Martínez, Marycarmen, Cidad, Pilar, García-Mateo, Nadia, Moreno-Estar, Sara, Serna, Julia, Fernández, Mirella, Swärd, Karl, Simarro-Grande, María, Fuente, Miguel A. de la, López-López, José R., Pérez-García, M. Teresa
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219761
Acceso en línea:http://hdl.handle.net/10261/219761
Access Level:acceso abierto
Descripción
Sumario:[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1.3 functional expression is relevant for PM in several types of vascular lesions. Here, we explore the efficacy of Kv1.3 inhibition for the prevention of remodeling in human vessels, and the mechanisms linking the switch in Kv1.3 /Kv1.5 ratio to PM.

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