Myocardin-dependent Kv1.5 channel expression prevents phenotypic modulation of human vessels in organ culture

[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1.3 functional expression is relevant for PM in sev...

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Detalhes bibliográficos
Autores: Arévalo-Martínez, Marycarmen, Cidad, Pilar, García-Mateo, Nadia, Moreno-Estar, Sara, Serna, Julia, Fernández, Mirella, Swärd, Karl, Simarro-Grande, María, Fuente, Miguel A. de la, López-López, José R., Pérez-García, M. Teresa
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219761
Acesso em linha:http://hdl.handle.net/10261/219761
Access Level:acceso abierto
Descrição
Resumo:[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1.3 functional expression is relevant for PM in several types of vascular lesions. Here, we explore the efficacy of Kv1.3 inhibition for the prevention of remodeling in human vessels, and the mechanisms linking the switch in Kv1.3 /Kv1.5 ratio to PM.

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