Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming co...

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Authors: Giménez Morales, Cristina, de la Torre, Cristina, Gorbe, Mónica, Amoros del Toro, Pedro Jose, Aznar, Elena|||0000-0003-0361-3876, Sancenón Galarza, Félix|||0000-0002-5205-7135, Murguía, Jose R.|||0000-0001-9364-4603, Martínez-Máñez, Ramón|||0000-0001-5873-9674, Marcos Martínez, María Dolores|||0000-0001-7079-8589
Format: article
Publication Date:2015
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/64798
Online Access:https://riunet.upv.es/handle/10251/64798
Access Level:Open access
Keyword:POLYMER HYBRID NANOPARTICLES
CONTROLLED-RELEASE
ENHANCED PERMEABILITY
INORGANIC NANOPARTICLES
TRIGGERED RELEASE
GUEST MOLECULES
IN-VITRO
GLUTATHIONE
SYSTEMS
SUPPORTS
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
BIOQUIMICA Y BIOLOGIA MOLECULAR
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network_name_str España
repository_id_str
spelling Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cellsGiménez Morales, Cristinade la Torre, CristinaGorbe, MónicaAmoros del Toro, Pedro JoseAznar, Elena|||0000-0003-0361-3876Sancenón Galarza, Félix|||0000-0002-5205-7135Murguía, Jose R.|||0000-0001-9364-4603Martínez-Máñez, Ramón|||0000-0001-5873-9674Marcos Martínez, María Dolores|||0000-0001-7079-8589POLYMER HYBRID NANOPARTICLESCONTROLLED-RELEASEENHANCED PERMEABILITYINORGANIC NANOPARTICLESTRIGGERED RELEASEGUEST MOLECULESIN-VITROGLUTATHIONESYSTEMSSUPPORTSQUIMICA INORGANICAQUIMICA ORGANICAQUIMICA ANALITICAINGENIERIA DE LA CONSTRUCCIONBIOQUIMICA Y BIOLOGIA MOLECULARIn recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-) capped MSNs that are able to deliver safranin O and doxorubicin in a controlled manner. The results showed that the PEG-capped systems designed in this work can be maintained closed at low GSH concentrations, yet the cargo can be delivered when the concentration of GSH is increased. Moreover, the efficacy of the PEG-capped system in delivering the cytotoxic agent doxorubicin in cells was also demonstrated.The authors thank the Spanish Government (Project MAT2012-38429-C04-01), the Generalitat Valenciana (Project PROMETEOII/2014/047), and the Universitat Politecnica de Valencia (Project SP20120795) for support. C.G. and C.d.l.T also thank the Spanish Ministry of Education for their FPU grants. The authors also thank UPV electron microscopy and CIPF confocal microscopy services for technical support.American Chemical SocietyDepartamento de BiotecnologíaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de QuímicaEscuela Técnica Superior de Ingeniería IndustrialInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo TecnológicoEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalGeneralitat ValencianaUniversitat Politècnica de ValènciaMinisterio de Economía y CompetitividadMinisterio de EducaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20152015-03-31journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/64798reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2012-38429-C04-01 DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y COGeneralitat Valenciana https://doi.org/10.13039/501100003359 PROMETEOII%2F2014%2F047 Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrososUniversitat Politècnica de València https://doi.org/10.13039/501100004233 SP20120795open accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/647982026-06-13T07:49:27Z
dc.title.none.fl_str_mv Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
title Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
spellingShingle Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
Giménez Morales, Cristina
POLYMER HYBRID NANOPARTICLES
CONTROLLED-RELEASE
ENHANCED PERMEABILITY
INORGANIC NANOPARTICLES
TRIGGERED RELEASE
GUEST MOLECULES
IN-VITRO
GLUTATHIONE
SYSTEMS
SUPPORTS
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
BIOQUIMICA Y BIOLOGIA MOLECULAR
title_short Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
title_full Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
title_fullStr Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
title_full_unstemmed Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
title_sort Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
dc.creator.none.fl_str_mv Giménez Morales, Cristina
de la Torre, Cristina
Gorbe, Mónica
Amoros del Toro, Pedro Jose
Aznar, Elena|||0000-0003-0361-3876
Sancenón Galarza, Félix|||0000-0002-5205-7135
Murguía, Jose R.|||0000-0001-9364-4603
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Marcos Martínez, María Dolores|||0000-0001-7079-8589
author Giménez Morales, Cristina
author_facet Giménez Morales, Cristina
de la Torre, Cristina
Gorbe, Mónica
Amoros del Toro, Pedro Jose
Aznar, Elena|||0000-0003-0361-3876
Sancenón Galarza, Félix|||0000-0002-5205-7135
Murguía, Jose R.|||0000-0001-9364-4603
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Marcos Martínez, María Dolores|||0000-0001-7079-8589
author_role author
author2 de la Torre, Cristina
Gorbe, Mónica
Amoros del Toro, Pedro Jose
Aznar, Elena|||0000-0003-0361-3876
Sancenón Galarza, Félix|||0000-0002-5205-7135
Murguía, Jose R.|||0000-0001-9364-4603
Martínez-Máñez, Ramón|||0000-0001-5873-9674
Marcos Martínez, María Dolores|||0000-0001-7079-8589
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biotecnología
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Química
Escuela Técnica Superior de Ingeniería Industrial
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Generalitat Valenciana
Universitat Politècnica de València
Ministerio de Economía y Competitividad
Ministerio de Educación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv POLYMER HYBRID NANOPARTICLES
CONTROLLED-RELEASE
ENHANCED PERMEABILITY
INORGANIC NANOPARTICLES
TRIGGERED RELEASE
GUEST MOLECULES
IN-VITRO
GLUTATHIONE
SYSTEMS
SUPPORTS
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
BIOQUIMICA Y BIOLOGIA MOLECULAR
topic POLYMER HYBRID NANOPARTICLES
CONTROLLED-RELEASE
ENHANCED PERMEABILITY
INORGANIC NANOPARTICLES
TRIGGERED RELEASE
GUEST MOLECULES
IN-VITRO
GLUTATHIONE
SYSTEMS
SUPPORTS
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
BIOQUIMICA Y BIOLOGIA MOLECULAR
description In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-) capped MSNs that are able to deliver safranin O and doxorubicin in a controlled manner. The results showed that the PEG-capped systems designed in this work can be maintained closed at low GSH concentrations, yet the cargo can be delivered when the concentration of GSH is increased. Moreover, the efficacy of the PEG-capped system in delivering the cytotoxic agent doxorubicin in cells was also demonstrated.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-03-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/64798
url https://riunet.upv.es/handle/10251/64798
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2012-38429-C04-01 DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO
Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEOII%2F2014%2F047 Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos
Universitat Politècnica de València https://doi.org/10.13039/501100004233 SP20120795
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422251986649088
score 15,301603

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