Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming co...

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Detalles Bibliográficos
Autores: Giménez Morales, Cristina, de la Torre, Cristina, Gorbe, Mónica, Amoros del Toro, Pedro Jose, Aznar, Elena|||0000-0003-0361-3876, Sancenón Galarza, Félix|||0000-0002-5205-7135, Murguía, Jose R.|||0000-0001-9364-4603, Martínez-Máñez, Ramón|||0000-0001-5873-9674, Marcos Martínez, María Dolores|||0000-0001-7079-8589
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/64798
Acceso en línea:https://riunet.upv.es/handle/10251/64798
Access Level:acceso abierto
Palabra clave:POLYMER HYBRID NANOPARTICLES
CONTROLLED-RELEASE
ENHANCED PERMEABILITY
INORGANIC NANOPARTICLES
TRIGGERED RELEASE
GUEST MOLECULES
IN-VITRO
GLUTATHIONE
SYSTEMS
SUPPORTS
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
BIOQUIMICA Y BIOLOGIA MOLECULAR
Descripción
Sumario:In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-) capped MSNs that are able to deliver safranin O and doxorubicin in a controlled manner. The results showed that the PEG-capped systems designed in this work can be maintained closed at low GSH concentrations, yet the cargo can be delivered when the concentration of GSH is increased. Moreover, the efficacy of the PEG-capped system in delivering the cytotoxic agent doxorubicin in cells was also demonstrated.

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