Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition

Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including brea...

Full description

Bibliographic Details
Authors: Bradbury, Kathryn E., Appleby, Paul N., Tipper, Sarah J., Travis, Ruth C., Allen, Naomi E., Kvaskoff, Marina, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Cervenka, Iris, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kaaks, Rudolf, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Vecchia, Carlo La, Stratigos, Alexander J., Palli, Domenico, Grioni, Sara, Matullo, Giuseppe, Panico, Salvatore, Tumino, Rosario, Peeters, Petra H. M., Bueno de Mesquita, H. Bas, Ghiasvand, Reza, Veierød, Marit B., Weiderpass, Elisabete, Bonet Bonet, Catalina, Molina, Elena, Huerta Castaño, José María, Larrañaga, Nerea, Barricarte, Aurelio, Merino, Susana, Isaksson, Karolin, Stocks, Tanja, Ljuslinder, Ingrid, Hemmingsson, Oskar, Wareham, Nick, Khaw, Kay‐Tee, Gunter, Marc J., Rinaldi, Sabina, Tsilidis, Konstantinos K., Aune, Dagfinn, Riboli, Elio, Key, Timothy J.
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/174961
Online Access:https://hdl.handle.net/2445/174961
Access Level:Open access
Keyword:Càncer
Nutrició
Insulina
Cancer
Nutrition
Insulin
Description
Summary:Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

Similar Items