Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer ris...

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Detalles Bibliográficos
Autores: Kliemann, Nathalie, Murphy, Neil, Viallon, Vivian, Freisling, Heinz, Tsilidis, Konstantinos K., Rinaldi, Sabina, Mancini, Francesca Romana, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Boeing, Heiner, Schulze, Matthias B., Masala, Giovanna, Krogh, Vittorio, Sacerdote, Carlotta, Santucci de Magistris, Maria, Bueno de Mesquita, H. Bas, Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Jakszyn, Paula, Redondo Sánchez, Daniel, Amiano, Pilar, Chirlaque, María Dolores, Barricarte, Aurelio, Ericson, Ulrika, Drake, Isabel, Nøst, Therese Haugdahl, Aune, Dagfinn, May, Anne M., Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Tumino, Rosario, Quirós, José Ramón, Trichopoulou, Antonia, Karakatsani, Anna, Vecchia, Carlo La, Nilsson, Lena Maria, Riboli, Elio, Huybrechts, Inge, Gunter, Marc J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171741
Acceso en línea:https://hdl.handle.net/2445/171741
Access Level:acceso abierto
Palabra clave:Càncer
Nutrició
Cancer
Nutrition
Descripción
Sumario:Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

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