Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model

This article belongs to the Special Issue Bioactive Compounds and Functional Foods in Human Health—2nd Edition.

Detalles Bibliográficos
Autores: Gómez García, Iker, Fernández Quintela, Alfredo, Oliver, Paula, Picó, Catalina, Cano, M. Pilar, Portillo, María P., Trepiana, Jenifer
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/404685
Acceso en línea:http://hdl.handle.net/10261/404685
Access Level:acceso abierto
Palabra clave:Opuntia stricta var. dillenii
Obesity
Prickly pear
Betalains
Phenolic compounds
Adipose tissue
High-fat high-fructose diet
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spelling Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal modelGómez García, IkerFernández Quintela, AlfredoOliver, PaulaPicó, CatalinaCano, M. PilarPortillo, María P.Trepiana, JeniferOpuntia stricta var. dilleniiObesityPrickly pearBetalainsPhenolic compoundsAdipose tissueHigh-fat high-fructose dietThis article belongs to the Special Issue Bioactive Compounds and Functional Foods in Human Health—2nd Edition.[Background] Due to the continuous global rise in obesity prevalence, foods rich in bioactive compounds are increasingly recognised for the management of several diseases.[Objective] The present study aims to investigate whether an Opuntia stricta var. dillenii fruit peel extract, rich in betalains and phenolic compounds, is able to prevent obesity induced by a high-fat high-fructose diet in rats, along with the potential mechanisms of action underlying this effect.[Results] The supplementation with Opuntia stricta var. dillenii extract obtained from the peel fruit partially prevents obesity development by attenuating HFHF-induced fat accumulation. This effect was observed predominantly in visceral adipose tissue, rather than in the subcutaneous depot. The obesity prevention was accompanied by the improvement of serum lipid profile. The mechanisms underlying the extract anti-obesity effect which were analysed in epididymal adipose tissue, involve preventing the rise in the availability of triglyceride synthesis substrates induced by high-fat high-fructose feeding, the inhibition of triglyceride assembly, and in the case of the high dose, increased lipolysis.[Conclusions] According to these results, the peel wastes of Opuntia stricta var. dillenii fruit represent a promising natural source of bioactive compounds for obesity prevention. Nevertheless, these preclinical effects should be replicated in further studies in human beings.This research was funded by the Ministerio de Ciencia e Innovación (PID2020-118300RBC22 and PID2020-118300RB-C21 projects) and co-funded by MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”, the Government of the Basque Country (IT1482-22) and CIBEROBN (CB12/03/30007).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionEusko JaurlaritzaCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España)Instituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/404685reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118300RB-C22info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118300RB-C21https://doi.org/10.3390/nu17193178Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4046852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
title Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
spellingShingle Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
Gómez García, Iker
Opuntia stricta var. dillenii
Obesity
Prickly pear
Betalains
Phenolic compounds
Adipose tissue
High-fat high-fructose diet
title_short Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
title_full Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
title_fullStr Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
title_full_unstemmed Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
title_sort Preventive effects of an Opuntia stricta var. dillenii extract on lipid metabolism in a high-fat high-fructose diet-induced obesity animal model
dc.creator.none.fl_str_mv Gómez García, Iker
Fernández Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M. Pilar
Portillo, María P.
Trepiana, Jenifer
author Gómez García, Iker
author_facet Gómez García, Iker
Fernández Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M. Pilar
Portillo, María P.
Trepiana, Jenifer
author_role author
author2 Fernández Quintela, Alfredo
Oliver, Paula
Picó, Catalina
Cano, M. Pilar
Portillo, María P.
Trepiana, Jenifer
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Eusko Jaurlaritza
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España)
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Opuntia stricta var. dillenii
Obesity
Prickly pear
Betalains
Phenolic compounds
Adipose tissue
High-fat high-fructose diet
topic Opuntia stricta var. dillenii
Obesity
Prickly pear
Betalains
Phenolic compounds
Adipose tissue
High-fat high-fructose diet
description This article belongs to the Special Issue Bioactive Compounds and Functional Foods in Human Health—2nd Edition.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/404685
url http://hdl.handle.net/10261/404685
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118300RB-C22
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118300RB-C21
https://doi.org/10.3390/nu17193178
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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