Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.

The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine...

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Detalles Bibliográficos
Autores: Baulida i Estadella, Josep, 1965-, García de Herreros, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/24846
Acceso en línea:http://hdl.handle.net/10230/24846
http://dx.doi.org/10.1016/j.bbcan.2015.05.005
Access Level:acceso abierto
Palabra clave:Metastasis
EMT Epithelial to mesenchymal transition
Snail1
CAF Cancer associated fibroblasts
CSC Cancer stem cell
Tumor microenvironment
Mechanical signalling
TGF-beta
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spelling Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.Baulida i Estadella, Josep, 1965-García de Herreros, AntonioMetastasisEMT Epithelial to mesenchymal transitionSnail1CAF Cancer associated fibroblastsCSC Cancer stem cellTumor microenvironmentMechanical signallingTGF-betaThe transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine signaling and propose that Snail1 orchestrates the generation of cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs). Our view supports the current models for tumorigenesis that consider stemness and tumor microenvironment as retroactive actors for metastasis formation, revealing Snail1 as a regulator of these metastatic forces. This view offers new perspectives for understanding and targeting metastasis.Elsevier201520162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/24846http://dx.doi.org/10.1016/j.bbcan.2015.05.005reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiochimica et Biophysica Acta. 2015 Aug;1856(1):55-61© 2015 Elsevier B.V. All rights reservedinfo:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/248462026-06-12T07:21:37Z
dc.title.none.fl_str_mv Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
title Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
spellingShingle Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
Baulida i Estadella, Josep, 1965-
Metastasis
EMT Epithelial to mesenchymal transition
Snail1
CAF Cancer associated fibroblasts
CSC Cancer stem cell
Tumor microenvironment
Mechanical signalling
TGF-beta
title_short Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
title_full Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
title_fullStr Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
title_full_unstemmed Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
title_sort Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
dc.creator.none.fl_str_mv Baulida i Estadella, Josep, 1965-
García de Herreros, Antonio
author Baulida i Estadella, Josep, 1965-
author_facet Baulida i Estadella, Josep, 1965-
García de Herreros, Antonio
author_role author
author2 García de Herreros, Antonio
author2_role author
dc.subject.none.fl_str_mv Metastasis
EMT Epithelial to mesenchymal transition
Snail1
CAF Cancer associated fibroblasts
CSC Cancer stem cell
Tumor microenvironment
Mechanical signalling
TGF-beta
topic Metastasis
EMT Epithelial to mesenchymal transition
Snail1
CAF Cancer associated fibroblasts
CSC Cancer stem cell
Tumor microenvironment
Mechanical signalling
TGF-beta
description The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine signaling and propose that Snail1 orchestrates the generation of cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs). Our view supports the current models for tumorigenesis that consider stemness and tumor microenvironment as retroactive actors for metastasis formation, revealing Snail1 as a regulator of these metastatic forces. This view offers new perspectives for understanding and targeting metastasis.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/24846
http://dx.doi.org/10.1016/j.bbcan.2015.05.005
url http://hdl.handle.net/10230/24846
http://dx.doi.org/10.1016/j.bbcan.2015.05.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta. 2015 Aug;1856(1):55-61
dc.rights.none.fl_str_mv © 2015 Elsevier B.V. All rights reserved
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2015 Elsevier B.V. All rights reserved
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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