Snail1: a transcriptional factor controlled at multiple levels
Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific...
| Autores: | , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/43518 |
| Acesso em linha: | http://hdl.handle.net/10230/43518 http://dx.doi.org/10.3390/jcm8060757 |
| Access Level: | acceso abierto |
| Palavra-chave: | Epithelial to mesenchymal transition (EMT) Snail1 Drug resistance Transcriptional factor Tumor invasion |
| Resumo: | Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator. |
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