Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particula...

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Detalles Bibliográficos
Autores: Gaudêncio, S.P., Bayram, E., Luki? Bilela, L., Cueto, M., Díaz-Marrero, A.R., Haznedaroglu, B.Z., Jiménez González, Carlos, Mandalakis, M., Pereira, F., Reyes, F., Tasdemir, D.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21027
Acceso en línea:https://portalcientifico.sergas.gal//documentos/648600d5a219857f1d789560
http://hdl.handle.net/20.500.11940/21027
Access Level:acceso abierto
Palabra clave:Biological Products
Databases, Factual
Metabolomics
Computational Biology
Genomics
INIBIC
Descripción
Sumario:Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.

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