Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study
Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated w...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/17873 |
| Acesso em linha: | http://hdl.handle.net/10902/17873 |
| Access Level: | acceso abierto |
| Palavra-chave: | Alkylphenolic Compounds Alkylphenols Breast Cancer Job-Exposure Matrix Occupational Exposure Prostate Cancer |
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España |
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| dc.title.none.fl_str_mv |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| title |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| spellingShingle |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study Peremiquel-Trillas, Paula Alkylphenolic Compounds Alkylphenols Breast Cancer Job-Exposure Matrix Occupational Exposure Prostate Cancer |
| title_short |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| title_full |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| title_fullStr |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| title_full_unstemmed |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| title_sort |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study |
| dc.creator.none.fl_str_mv |
Peremiquel-Trillas, Paula Benavente, Yolanda Martín-Bustamante, Mayte Casabonne, Delphine Pérez-Gómez, Beatriz Gómez Acebo, Inés Oliete-Canela, Anna Diéguez-Rodríguez, Marta Tusquets, Ignasi Amiano, Pilar Mengual, Lourdes Ardanaz, Eva Capelo, Rocío Molina de la Torre, Antonio J. Salas Trejo, Dolores Fernández-Tardón, Guillermo Lope, Virginia Jimenez-Moleon, José J. Marcos-Gragera, Rafael Dierssen Sotos, Trinidad |
| author |
Peremiquel-Trillas, Paula |
| author_facet |
Peremiquel-Trillas, Paula Benavente, Yolanda Martín-Bustamante, Mayte Casabonne, Delphine Pérez-Gómez, Beatriz Gómez Acebo, Inés Oliete-Canela, Anna Diéguez-Rodríguez, Marta Tusquets, Ignasi Amiano, Pilar Mengual, Lourdes Ardanaz, Eva Capelo, Rocío Molina de la Torre, Antonio J. Salas Trejo, Dolores Fernández-Tardón, Guillermo Lope, Virginia Jimenez-Moleon, José J. Marcos-Gragera, Rafael Dierssen Sotos, Trinidad |
| author_role |
author |
| author2 |
Benavente, Yolanda Martín-Bustamante, Mayte Casabonne, Delphine Pérez-Gómez, Beatriz Gómez Acebo, Inés Oliete-Canela, Anna Diéguez-Rodríguez, Marta Tusquets, Ignasi Amiano, Pilar Mengual, Lourdes Ardanaz, Eva Capelo, Rocío Molina de la Torre, Antonio J. Salas Trejo, Dolores Fernández-Tardón, Guillermo Lope, Virginia Jimenez-Moleon, José J. Marcos-Gragera, Rafael Dierssen Sotos, Trinidad |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Alkylphenolic Compounds Alkylphenols Breast Cancer Job-Exposure Matrix Occupational Exposure Prostate Cancer |
| topic |
Alkylphenolic Compounds Alkylphenols Breast Cancer Job-Exposure Matrix Occupational Exposure Prostate Cancer |
| description |
Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case-control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02-1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10902/17873 |
| url |
http://hdl.handle.net/10902/17873 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Environ Int. 2019 Jan;122:389-399 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
| instname_str |
Universidad de Cantabria (UC) |
| reponame_str |
UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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| _version_ |
1869422176257441792 |
| spelling |
Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain studyPeremiquel-Trillas, PaulaBenavente, YolandaMartín-Bustamante, MayteCasabonne, DelphinePérez-Gómez, BeatrizGómez Acebo, InésOliete-Canela, AnnaDiéguez-Rodríguez, MartaTusquets, IgnasiAmiano, PilarMengual, LourdesArdanaz, EvaCapelo, RocíoMolina de la Torre, Antonio J.Salas Trejo, DoloresFernández-Tardón, GuillermoLope, VirginiaJimenez-Moleon, José J.Marcos-Gragera, RafaelDierssen Sotos, TrinidadAlkylphenolic CompoundsAlkylphenolsBreast CancerJob-Exposure MatrixOccupational ExposureProstate CancerBackground: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case-control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02-1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.This work was partially funded by the public grants from the Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733, SLT006/17/76), and European Regional Development Fund-ERDF, by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos IIIFEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179), by the Fundación Marqués de Valdecilla (API 10/09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) grants 2014SGR647 and 2014SGR850. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.ElsevierUniversidad de Cantabria20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/17873Environ Int. 2019 Jan;122:389-399reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/178732026-06-02T12:39:31Z |
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15,301603 |