Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

[EN] Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investiga...

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Detalhes bibliográficos
Autores: Peremiquel Trillas, Paula, Benavente, Yolanda, Martín Bustamante, Mayte, Casabonne, Delphine, Pérez Gómez, Beatriz, Gómez Acebo, Inés, Oliete Canela, Anna, Diéguez Rodríguez, Marta, Tusquets, Ignasi, Amiano, Pilar, Mengual, Lourdes, Ardanaz, Eva, Capelo, Rocío, Molina de la Torre, Antonio José, Salas Trejo, Dolores, Fernández Tardón, Guillermo, Lope, Virginia, Jiménez Moleón, José J., Marcos Gragera, Rafael, Dierssen Sotos, Trinidad, Azpiri, Mikel, Muñoz, Montse, Guevara, Marcela, Fernández Villa, Tania, Molina Barceló, Ana, Aragonés, Nuria, Pollán, Marina, Castaño Vinyals, Gemma, Alguacil, Juan, Kogevinas, Manolis, Sanjosé, Silvia de, Costas, Laura
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/22312
Acesso em linha:https://www.sciencedirect.com/science/article/pii/S0160412018317744?via%3Dihub
https://hdl.handle.net/10612/22312
Access Level:acceso abierto
Palavra-chave:Medicina. Salud
Alkylphenols
Alkylphenolic compounds
Job-exposure matrix
Breast cancer
Prostate cancer
Occupational exposure
Descrição
Resumo:[EN] Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies

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