Circulating citric acid cycle metabolites and risk of cardiovascular disease in the PREDIMED study

Plasma citric acid cycle (CAC) metabolites might be likely related to cardiovascular disease (CVD). However, studies assessing the longitudinal associations between circulating CAC-related metabolites and CVD risk are lacking. The aim of this study was to evaluate the association of baseline and 1-y...

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Detalhes bibliográficos
Autores: Santos, José L, Ruiz-Canela, Miguel, Razquin, Cristina, Clish, Clary B., Guasch-Ferré, Marta, Babio, Nancy, Corella, Dolores, Gómez-Gracia, Enrique, Fiol Sala, Miquel, Estruch, Ramon, Lapetra, José, Fito, Montserrat, Aros, Fernando, Serra-Majem, Lluis, Liang, Liming, Martínez, María Ángeles, Toledo, Estefanía, Salas-Salvado, Jordi, Hu, Frank B, Martínez-González, Miguel Ángel
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:Docusalut
Idioma:inglês
OAI Identifier:oai:docusalut.com:20.500.13003/18861
Acesso em linha:https://hdl.handle.net/20.500.13003/18861
Access Level:Acceso aberto
Palavra-chave:Cardiovascular Diseases
Aged, 80 and over
Aged
Case-Control Studies
Citric Acid Cycle
Humans
Middle Aged
Male
Malates
Female
Risk Factors
Diet, Mediterranean
Cohort Studies
Dieta Mediterránea
Estudios de Cohortes
Malatos
Femenino
Masculino
Factores de Riesgo
Humanos
Persona de Mediana Edad
Ciclo del Ácido Cítrico
Anciano
Anciano de 80 o más Años
Enfermedades Cardiovasculares
Estudios de Casos y Controles
Descrição
Resumo:Plasma citric acid cycle (CAC) metabolites might be likely related to cardiovascular disease (CVD). However, studies assessing the longitudinal associations between circulating CAC-related metabolites and CVD risk are lacking. The aim of this study was to evaluate the association of baseline and 1-year levels of plasma CAC-related metabolites with CVD incidence (a composite of myocardial infarction, stroke or cardiovascular death), and their interaction with Mediterranean diet interventions. Case-cohort study from the PREDIMED trial involving participants aged 55-80 years at high cardiovascular risk, allocated to MedDiets or control diet. A subcohort of 791 participants was selected at baseline, and a total of 231 cases were identified after a median follow-up of 4.8 years. Nine plasma CAC-related metabolites (pyruvate, lactate, citrate, aconitate, isocitrate, 2-hydroxyglutarate, fumarate, malate and succinate) were measured using liquid chromatography-tandem mass spectrometry. Weighted Cox multiple regression was used to calculate hazard ratios (HRs). Baseline fasting plasma levels of 3 metabolites were associated with higher CVD risk, with HRs (for each standard deviation, 1-SD) of 1.46 (95%CI:1.20-1.78) for 2-hydroxyglutarate, 1.33 (95%CI:1.12-1.58) for fumarate and 1.47 (95%CI:1.21-1.78) for malate (p of linear trend <0.001 for all). A higher risk of CVD was also found for a 1-SD increment of a combined score of these 3 metabolites (HR = 1.60; 95%CI: 1.32-1.94, p trend <0.001). This result was replicated using plasma measurements after one-year. No interactions were detected with the nutritional intervention. Plasma 2-hydroxyglutarate, fumarate and malate levels were prospectively associated with increased cardiovascular risk. ISRCTN35739639.

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