Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter

Objectives. Pulsed electric field (PEF) therapies employ punctuated energy delivery to kill cells in a volume of tissue through mechanisms that are not dependent on thermal processes. A key component to successful cardiac ablation procedures is ensuring the generation of transmural, contiguous ablat...

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Detalles Bibliográficos
Autores: Verma, Atul, Neal, Robert, Evans, John, Castellví, Quim, Vachani, Armaan, Deneke, Thomas, Nakagawa, Hiroshi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/70222
Acceso en línea:http://hdl.handle.net/10230/70222
http://dx.doi.org/10.1111/jce.15734
Access Level:acceso abierto
Palabra clave:Aliya
CENTAURI
Dose
Electroporation
Lesion
Size
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repository_id_str
spelling Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheterVerma, AtulNeal, RobertEvans, JohnCastellví, QuimVachani, ArmaanDeneke, ThomasNakagawa, HiroshiAliyaCENTAURIDoseElectroporationLesionSizeObjectives. Pulsed electric field (PEF) therapies employ punctuated energy delivery to kill cells in a volume of tissue through mechanisms that are not dependent on thermal processes. A key component to successful cardiac ablation procedures is ensuring the generation of transmural, contiguous ablation zones, which requires in-depth knowledge regarding treatment sizes for a given therapeutic application. Methods. In this study, a series of acute treatments were delivered to porcine ventricles, where triphenyl tetrazolium chloride (TTC) vitality stain was used to identify treatment effect sizes for the three focal monopolar CENTAURI PEF cardiac ablation energy settings. Results. Treatment depths were 5.7, 7.2, and 8.2 mm for the 19, 22, and 25 A energy settings, respectively. Gross pathology indicated umbral zones of hemorrhage surrounded by pale avital TTC-negative-negative tissue, which contrasted significantly from radiofrequency ablation (RF) controls. Histologically, treatment zones are identified by regions of contraction band necrosis and cardiomyocytolysis, which contrasted with RF control lesions composed primarily of coagulation necrosis. Conclusions. Together, these data indicate the ability for focal monopolar PEF treatments to generate deep treatment zones in cardiac ablation without incurring the gross or histological coagulative characteristics of RF thermal lesions.Wiley202520252023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70222http://dx.doi.org/10.1111/jce.15734reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJournal of Cardiovascular Electrophysiology. 2023 Jan;34(1):99-107© 2022 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/702222026-06-12T07:21:37Z
dc.title.none.fl_str_mv Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
title Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
spellingShingle Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
Verma, Atul
Aliya
CENTAURI
Dose
Electroporation
Lesion
Size
title_short Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
title_full Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
title_fullStr Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
title_full_unstemmed Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
title_sort Characteristics of pulsed electric field cardiac ablation porcine treatment zones with a focal catheter
dc.creator.none.fl_str_mv Verma, Atul
Neal, Robert
Evans, John
Castellví, Quim
Vachani, Armaan
Deneke, Thomas
Nakagawa, Hiroshi
author Verma, Atul
author_facet Verma, Atul
Neal, Robert
Evans, John
Castellví, Quim
Vachani, Armaan
Deneke, Thomas
Nakagawa, Hiroshi
author_role author
author2 Neal, Robert
Evans, John
Castellví, Quim
Vachani, Armaan
Deneke, Thomas
Nakagawa, Hiroshi
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Aliya
CENTAURI
Dose
Electroporation
Lesion
Size
topic Aliya
CENTAURI
Dose
Electroporation
Lesion
Size
description Objectives. Pulsed electric field (PEF) therapies employ punctuated energy delivery to kill cells in a volume of tissue through mechanisms that are not dependent on thermal processes. A key component to successful cardiac ablation procedures is ensuring the generation of transmural, contiguous ablation zones, which requires in-depth knowledge regarding treatment sizes for a given therapeutic application. Methods. In this study, a series of acute treatments were delivered to porcine ventricles, where triphenyl tetrazolium chloride (TTC) vitality stain was used to identify treatment effect sizes for the three focal monopolar CENTAURI PEF cardiac ablation energy settings. Results. Treatment depths were 5.7, 7.2, and 8.2 mm for the 19, 22, and 25 A energy settings, respectively. Gross pathology indicated umbral zones of hemorrhage surrounded by pale avital TTC-negative-negative tissue, which contrasted significantly from radiofrequency ablation (RF) controls. Histologically, treatment zones are identified by regions of contraction band necrosis and cardiomyocytolysis, which contrasted with RF control lesions composed primarily of coagulation necrosis. Conclusions. Together, these data indicate the ability for focal monopolar PEF treatments to generate deep treatment zones in cardiac ablation without incurring the gross or histological coagulative characteristics of RF thermal lesions.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70222
http://dx.doi.org/10.1111/jce.15734
url http://hdl.handle.net/10230/70222
http://dx.doi.org/10.1111/jce.15734
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Cardiovascular Electrophysiology. 2023 Jan;34(1):99-107
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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