Analytical model of large-diameter spherical-like catheter for pulsed field ablation in treating cardiac arrhythmias
[EN] Objective. To study the electrical performance of large-diameter spherical-like catheters used for pulsed field ablation (PFA) in treating cardiac arrhythmias, especially evaluating the effect of electrode radius, applied voltage and maximum current delivered on the PFA-induced lesion depth. Ap...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/232317 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/232317 |
| Access Level: | acceso abierto |
| Palabra clave: | Analytical model Arrhythmias Cardiac ablation Electroporation Pulsed field ablation Spherical electrode |
| Sumario: | [EN] Objective. To study the electrical performance of large-diameter spherical-like catheters used for pulsed field ablation (PFA) in treating cardiac arrhythmias, especially evaluating the effect of electrode radius, applied voltage and maximum current delivered on the PFA-induced lesion depth. Approach. An analytical model was proposed which used spherical coordinates to estimate the value of the electric field around a spherical metal electrode. Lesion depth was estimated by the myocardium lethal electric field threshold. The paper also reviews the literature and proposes a relationship between this threshold and the total cumulative duration of the pulses applied during PFA. Main results. Despite the models simplicity in geometric terms, the estimated values of baseline impedance (44 Omega) and impedance drop due to PFA (7-9 Omega) are closely related to those observed in experimental studies (43 Omega and 5-7 Omega, respectively). The PFA-induced lesion size potentially increases with the applied voltage, but this is only true if the generator can provide the electrical current needed to maintain the required voltage. A nonlinear relationship was identified between PFA-induced lesion depth and the electrode diameter, which was also modulated by the total duration. Significance. The analytical model offers a physical explanation for the PFA-Induced electrical phenomenon, while emphasising how certain technical characteristics (maximum current, applied voltage, electrode diameter) can affect the depth of the lesion. |
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