Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form

Optically active cis-, 8a and 8b, and trans-1-aminomethyl-2-phenylcyclohexane-1-carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol of stereocontrolled reactions. Subsequent cy...

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Detalhes bibliográficos
Autores: Avenoza, A. [0000-0002-5465-3555], Cativiela, C., París, M., Peregrina, J.M. [0000-0003-3778-7065]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:1995
País:España
Recursos:Universidad de La Rioja (UR)
Repositório:RIUR. Repositorio Institucional de la Universidad de La Rioja
OAI Identifier:oai:portal.dialnet.es:doc/5bbc68fdb750603269e81302
Acesso em linha:https://investigacion.unirioja.es/documentos/5bbc68fdb750603269e81302
Access Level:Acceso aberto
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spelling Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure formAvenoza, A. [0000-0002-5465-3555]Cativiela, C.París, M.Peregrina, J.M. [0000-0003-3778-7065]Optically active cis-, 8a and 8b, and trans-1-aminomethyl-2-phenylcyclohexane-1-carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol of stereocontrolled reactions. Subsequent cyclization of these conformationally constrained β-amino acids led to the corresponding α,α-disubstituted-β-lactams 10a, 10b, 11a and 11b in enantiomerically pure forms.1995info:eu-repo/semantics/articleSubtype: Articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://investigacion.unirioja.es/documentos/5bbc68fdb750603269e81302reponame:RIUR. Repositorio Institucional de la Universidad de La Riojainstname:Universidad de La Rioja (UR)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/0957-4166(95)00174-Ninfo:eu-repo/semantics/altIdentifier/wos/WOS:A1995RF00500027info:eu-repo/semantics/altIdentifier/pissn/0957-4166Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form, 1995, vol. 6, núm. 6, pág. 1409-1418info:eu-repo/semantics/openAccessoai:portal.dialnet.es:doc/5bbc68fdb750603269e813022026-06-14T12:47:17Z
dc.title.none.fl_str_mv Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
title Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
spellingShingle Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
Avenoza, A. [0000-0002-5465-3555]
title_short Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
title_full Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
title_fullStr Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
title_full_unstemmed Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
title_sort Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form
dc.creator.none.fl_str_mv Avenoza, A. [0000-0002-5465-3555]
Cativiela, C.
París, M.
Peregrina, J.M. [0000-0003-3778-7065]
author Avenoza, A. [0000-0002-5465-3555]
author_facet Avenoza, A. [0000-0002-5465-3555]
Cativiela, C.
París, M.
Peregrina, J.M. [0000-0003-3778-7065]
author_role author
author2 Cativiela, C.
París, M.
Peregrina, J.M. [0000-0003-3778-7065]
author2_role author
author
author
description Optically active cis-, 8a and 8b, and trans-1-aminomethyl-2-phenylcyclohexane-1-carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol of stereocontrolled reactions. Subsequent cyclization of these conformationally constrained β-amino acids led to the corresponding α,α-disubstituted-β-lactams 10a, 10b, 11a and 11b in enantiomerically pure forms.
publishDate 1995
dc.date.none.fl_str_mv 1995
dc.type.none.fl_str_mv info:eu-repo/semantics/article
Subtype: Article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://investigacion.unirioja.es/documentos/5bbc68fdb750603269e81302
url https://investigacion.unirioja.es/documentos/5bbc68fdb750603269e81302
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/0957-4166(95)00174-N
info:eu-repo/semantics/altIdentifier/wos/WOS:A1995RF00500027
info:eu-repo/semantics/altIdentifier/pissn/0957-4166
Synthesis of a new type of conformationally constrained alfa, alfa-disubstituted-beta-amino acids and beta-lactams in enantiomerically pure form, 1995, vol. 6, núm. 6, pág. 1409-1418
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instname:Universidad de La Rioja (UR)
instname_str Universidad de La Rioja (UR)
reponame_str RIUR. Repositorio Institucional de la Universidad de La Rioja
collection RIUR. Repositorio Institucional de la Universidad de La Rioja
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