ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a...

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Autores: Royo, Romina, Magnano, Laura, Delgado, Julio, Ruiz Gil, Sara, Gelpi Buchaca, Josep Lluís, Heyn, Holger, Taylor, Malcom A., Stankovic, Tatjana, Puente, Xose S., Nadeu Prat, Ferran, Campo Güerri, Elias
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/200343
Acceso en línea:https://hdl.handle.net/2445/200343
Access Level:acceso abierto
Palabra clave:Leucèmia limfocítica crònica
Genòmica
Joves
Chronic lymphocytic leukemia
Genomics
Youth
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spelling ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolutionRoyo, RominaMagnano, LauraDelgado, JulioRuiz Gil, SaraGelpi Buchaca, Josep LluísHeyn, HolgerTaylor, Malcom A.Stankovic, TatjanaPuente, Xose S.Nadeu Prat, FerranCampo Güerri, EliasLeucèmia limfocítica crònicaGenòmicaJovesChronic lymphocytic leukemiaGenomicsYouthChronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a first-degree relative with CLL. Families with multiple individuals affected with CLL and other related B-cell tumors have been described with contradictory findings regarding their potential early age at diagnosis. Despite these observations, our knowledge about the molecular profile and predisposing factors in AYA CLL is scarce.Springer Nature2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/2445/200343Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41408-022-00686-6Blood Cancer Journal, 2022, vol. 12, num. 6, p. 90https://doi.org/10.1038/s41408-022-00686-6cc-by (c) Royo, Romina et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2003432026-05-29T05:05:01Z
dc.title.none.fl_str_mv ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
title ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
spellingShingle ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
Royo, Romina
Leucèmia limfocítica crònica
Genòmica
Joves
Chronic lymphocytic leukemia
Genomics
Youth
title_short ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
title_full ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
title_fullStr ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
title_full_unstemmed ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
title_sort ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution
dc.creator.none.fl_str_mv Royo, Romina
Magnano, Laura
Delgado, Julio
Ruiz Gil, Sara
Gelpi Buchaca, Josep Lluís
Heyn, Holger
Taylor, Malcom A.
Stankovic, Tatjana
Puente, Xose S.
Nadeu Prat, Ferran
Campo Güerri, Elias
author Royo, Romina
author_facet Royo, Romina
Magnano, Laura
Delgado, Julio
Ruiz Gil, Sara
Gelpi Buchaca, Josep Lluís
Heyn, Holger
Taylor, Malcom A.
Stankovic, Tatjana
Puente, Xose S.
Nadeu Prat, Ferran
Campo Güerri, Elias
author_role author
author2 Magnano, Laura
Delgado, Julio
Ruiz Gil, Sara
Gelpi Buchaca, Josep Lluís
Heyn, Holger
Taylor, Malcom A.
Stankovic, Tatjana
Puente, Xose S.
Nadeu Prat, Ferran
Campo Güerri, Elias
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leucèmia limfocítica crònica
Genòmica
Joves
Chronic lymphocytic leukemia
Genomics
Youth
topic Leucèmia limfocítica crònica
Genòmica
Joves
Chronic lymphocytic leukemia
Genomics
Youth
description Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a first-degree relative with CLL. Families with multiple individuals affected with CLL and other related B-cell tumors have been described with contradictory findings regarding their potential early age at diagnosis. Despite these observations, our knowledge about the molecular profile and predisposing factors in AYA CLL is scarce.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/200343
url https://hdl.handle.net/2445/200343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41408-022-00686-6
Blood Cancer Journal, 2022, vol. 12, num. 6, p. 90
https://doi.org/10.1038/s41408-022-00686-6
dc.rights.none.fl_str_mv cc-by (c) Royo, Romina et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Royo, Romina et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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