ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a...

Descripción completa

Detalles Bibliográficos
Autores: Royo, Romina, Magnano, Laura, Delgado, Julio, Ruiz Gil, Sara, Gelpi Buchaca, Josep Lluís, Heyn, Holger, Taylor, Malcom A., Stankovic, Tatjana, Puente, Xose S., Nadeu Prat, Ferran, Campo Güerri, Elias
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/200343
Acceso en línea:https://hdl.handle.net/2445/200343
Access Level:acceso abierto
Palabra clave:Leucèmia limfocítica crònica
Genòmica
Joves
Chronic lymphocytic leukemia
Genomics
Youth
Descripción
Sumario:Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a first-degree relative with CLL. Families with multiple individuals affected with CLL and other related B-cell tumors have been described with contradictory findings regarding their potential early age at diagnosis. Despite these observations, our knowledge about the molecular profile and predisposing factors in AYA CLL is scarce.

Similares en LA Referencia