Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients

Eltrombopag (ELT) is a thrombopoietin-receptor agonist that stimulates platelet (PLT) production in patients with primary immune thrombocytopenia (ITP). One potential mechanism of ELT is modulating the inflammatory response by increasing PLTs binding to leucocytes. This study examined the effect of...

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Autores: Osuna-Gómez, R, Zamora, C, Novelli, S, Garcia-Pallarols, F, Rodriguez, Y, Domingo, A, Canet, M, Olivera, P, Mulet, M, Cantó, E, Valcarcel, D, Sanchez-Gonzalez, B, Vidal, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p18384
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18384
Access Level:acceso abierto
Palabra clave:autoimmune disease
cellular immunology
immunology
immunophenotyping
platelet immunology
thrombocytopenia
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spelling Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patientsOsuna-Gómez, RZamora, CNovelli, SGarcia-Pallarols, FRodriguez, YDomingo, ACanet, MOlivera, PMulet, MCantó, EValcarcel, DSanchez-Gonzalez, BVidal, Sautoimmune diseasecellular immunologyimmunologyimmunophenotypingplatelet immunologythrombocytopeniaEltrombopag (ELT) is a thrombopoietin-receptor agonist that stimulates platelet (PLT) production in patients with primary immune thrombocytopenia (ITP). One potential mechanism of ELT is modulating the inflammatory response by increasing PLTs binding to leucocytes. This study examined the effect of ELT on leucocyte-PLTs complexes in 38 ITP patients. Patients, predominantly females with a mean age of 59 years, underwent treatments like corticosteroids, intravenous immunoglobulin and splenectomy. Compared to healthy donors, ITP patients exhibited lower percentages of lymphocyte with bound PLTs, but similar monocyte- or neutrophil with bound PLTs. ELT treatment increased PLTs counts and all types of leucocyte with bound PLTs. Network analysis showed dynamic changes in leucocyte with bound PLTs relationships due to ELT. Machine learning indicated that higher percentages of monocytes with bound PLTs were linked to a better clinical response to ELT. A possible mechanism was an increased IL-10 production in monocytes with bound PLTs from responder patients. This study provides insights into the immunological changes in ITP patients undergoing ELT and suggests potential predictive biomarkers for treatment response and disease monitoring. In the peripheral blood of immune thrombocytopenia (ITP) patients who respond to eltrombopag, the percentage of monocytes with bound platelets (PLTs) is higher compared to non-responder patients. These monocytes with bound PLT showed increased IL-10 production and higher CD16 and CD14 expression compared to monocytes without bound PLTs. This indicates better platelet recovery and a more durable response in ITP patients (created with ).imageWILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18384BRITISH JOURNAL OF HAEMATOLOGYISSN: 00071048ISSNe: 13652141reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p183842026-06-14T12:41:47Z
dc.title.none.fl_str_mv Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
title Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
spellingShingle Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
Osuna-Gómez, R
autoimmune disease
cellular immunology
immunology
immunophenotyping
platelet immunology
thrombocytopenia
title_short Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
title_full Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
title_fullStr Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
title_full_unstemmed Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
title_sort Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients
dc.creator.none.fl_str_mv Osuna-Gómez, R
Zamora, C
Novelli, S
Garcia-Pallarols, F
Rodriguez, Y
Domingo, A
Canet, M
Olivera, P
Mulet, M
Cantó, E
Valcarcel, D
Sanchez-Gonzalez, B
Vidal, S
author Osuna-Gómez, R
author_facet Osuna-Gómez, R
Zamora, C
Novelli, S
Garcia-Pallarols, F
Rodriguez, Y
Domingo, A
Canet, M
Olivera, P
Mulet, M
Cantó, E
Valcarcel, D
Sanchez-Gonzalez, B
Vidal, S
author_role author
author2 Zamora, C
Novelli, S
Garcia-Pallarols, F
Rodriguez, Y
Domingo, A
Canet, M
Olivera, P
Mulet, M
Cantó, E
Valcarcel, D
Sanchez-Gonzalez, B
Vidal, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv autoimmune disease
cellular immunology
immunology
immunophenotyping
platelet immunology
thrombocytopenia
topic autoimmune disease
cellular immunology
immunology
immunophenotyping
platelet immunology
thrombocytopenia
description Eltrombopag (ELT) is a thrombopoietin-receptor agonist that stimulates platelet (PLT) production in patients with primary immune thrombocytopenia (ITP). One potential mechanism of ELT is modulating the inflammatory response by increasing PLTs binding to leucocytes. This study examined the effect of ELT on leucocyte-PLTs complexes in 38 ITP patients. Patients, predominantly females with a mean age of 59 years, underwent treatments like corticosteroids, intravenous immunoglobulin and splenectomy. Compared to healthy donors, ITP patients exhibited lower percentages of lymphocyte with bound PLTs, but similar monocyte- or neutrophil with bound PLTs. ELT treatment increased PLTs counts and all types of leucocyte with bound PLTs. Network analysis showed dynamic changes in leucocyte with bound PLTs relationships due to ELT. Machine learning indicated that higher percentages of monocytes with bound PLTs were linked to a better clinical response to ELT. A possible mechanism was an increased IL-10 production in monocytes with bound PLTs from responder patients. This study provides insights into the immunological changes in ITP patients undergoing ELT and suggests potential predictive biomarkers for treatment response and disease monitoring. In the peripheral blood of immune thrombocytopenia (ITP) patients who respond to eltrombopag, the percentage of monocytes with bound platelets (PLTs) is higher compared to non-responder patients. These monocytes with bound PLT showed increased IL-10 production and higher CD16 and CD14 expression compared to monocytes without bound PLTs. This indicates better platelet recovery and a more durable response in ITP patients (created with ).image
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18384
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18384
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv BRITISH JOURNAL OF HAEMATOLOGY
ISSN: 00071048
ISSNe: 13652141
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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