Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy

This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99...

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Detalles Bibliográficos
Autores: Company-Se, Georgina|||0000-0002-0473-4955, Nescolarde, Lexa|||0000-0001-6861-5106, Pajares Ruiz, Virginia|||0000-0002-0916-527X, Torrego, Alfons|||0000-0001-6624-2465, Riu, Pere J.|||0000-0003-0477-1972, Rosell Ferrer, Javier|||0000-0002-9691-328X, Bragos, Ramon|||0000-0002-1373-1588
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:277714
Acceso en línea:https://ddd.uab.cat/record/277714
https://dx.doi.org/urn:doi:10.1109/ACCESS.2022.3209809
Access Level:acceso abierto
Palabra clave:Bronchi
Bronchoscopy
Calibration
Electrical impedance spectroscopy (EIS)
Lung
Descripción
Sumario:This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0.001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs.

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