Effect of calibration for tissue differentiation between healthy and neoplasm lung using minimally invasive electrical impedance spectroscopy
his study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/374387 |
| Acceso en línea: | https://hdl.handle.net/2117/374387 https://dx.doi.org/10.1109/ACCESS.2022.3209809 |
| Access Level: | acceso abierto |
| Palabra clave: | Impedance (Electricity) Bronchoscopy Lungs Bronchi Calibration Electrical impedance spectroscopy (EIS) Lung Impedància (Electricitat) Broncoscòpia Pulmons Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica |
| Sumario: | his study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0.001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs. |
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