Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study

Background/ObjectivesObesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary tim...

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Autores: Dieberger A.M., Obermayer-Pietsch B., Harreiter J., Desoye G., van Poppel M.N.M., Simmons D., Corcoy R., Perez J.M.A., Kautzky-Willer A., Damm P., Mathiesen E., Jensen D.M., Andersen L.L.T., Dunne F., Lapolla A., Dalfra M.G., Bertolotto A., Jelsma J.G.M., Galjaard S., Wender-Ozegowska E., Zawiejska A., Hill D., Devlieger R., Snoek F.J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16681
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16681
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165961368&doi=10.1038%2fs41366-023-01347-9&partnerID=40&md5=2871c4dcd2401b7274302e3b15011950
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spelling Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI studyDieberger A.M.Obermayer-Pietsch B.Harreiter J.Desoye G.van Poppel M.N.M.Simmons D.Corcoy R.Perez J.M.A.Kautzky-Willer A.Damm P.Mathiesen E.Jensen D.M.Andersen L.L.T.Dunne F.Lapolla A.Dalfra M.G.Bertolotto A.Jelsma J.G.M.Galjaard S.Wender-Ozegowska E.Zawiejska A.Hill D.Devlieger R.Snoek F.J.Background/ObjectivesObesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex.Subjects/MethodsParticipants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI & GE; 29 kg/m(2) were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered.ResultsAlmost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (-0.520%; 95% CI: -1.011%, -0.031% and -4.649%; -7.876%, -1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (-0.145 & mu;g/l; -0.279 & mu;g/l, -0.005 & mu;g/l). No associations were found with birthweight or other cord blood parameters.ConclusionsMaternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.SPRINGERNATURE2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16681https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165961368&doi=10.1038%2fs41366-023-01347-9&partnerID=40&md5=2871c4dcd2401b7274302e3b15011950INTERNATIONAL JOURNAL OF OBESITYISSN: 03070565ISSNe: 14765497reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p166812026-06-14T12:41:47Z
dc.title.none.fl_str_mv Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
title Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
spellingShingle Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
Dieberger A.M.
title_short Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
title_full Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
title_fullStr Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
title_full_unstemmed Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
title_sort Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
dc.creator.none.fl_str_mv Dieberger A.M.
Obermayer-Pietsch B.
Harreiter J.
Desoye G.
van Poppel M.N.M.
Simmons D.
Corcoy R.
Perez J.M.A.
Kautzky-Willer A.
Damm P.
Mathiesen E.
Jensen D.M.
Andersen L.L.T.
Dunne F.
Lapolla A.
Dalfra M.G.
Bertolotto A.
Jelsma J.G.M.
Galjaard S.
Wender-Ozegowska E.
Zawiejska A.
Hill D.
Devlieger R.
Snoek F.J.
author Dieberger A.M.
author_facet Dieberger A.M.
Obermayer-Pietsch B.
Harreiter J.
Desoye G.
van Poppel M.N.M.
Simmons D.
Corcoy R.
Perez J.M.A.
Kautzky-Willer A.
Damm P.
Mathiesen E.
Jensen D.M.
Andersen L.L.T.
Dunne F.
Lapolla A.
Dalfra M.G.
Bertolotto A.
Jelsma J.G.M.
Galjaard S.
Wender-Ozegowska E.
Zawiejska A.
Hill D.
Devlieger R.
Snoek F.J.
author_role author
author2 Obermayer-Pietsch B.
Harreiter J.
Desoye G.
van Poppel M.N.M.
Simmons D.
Corcoy R.
Perez J.M.A.
Kautzky-Willer A.
Damm P.
Mathiesen E.
Jensen D.M.
Andersen L.L.T.
Dunne F.
Lapolla A.
Dalfra M.G.
Bertolotto A.
Jelsma J.G.M.
Galjaard S.
Wender-Ozegowska E.
Zawiejska A.
Hill D.
Devlieger R.
Snoek F.J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
description Background/ObjectivesObesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex.Subjects/MethodsParticipants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI & GE; 29 kg/m(2) were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered.ResultsAlmost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (-0.520%; 95% CI: -1.011%, -0.031% and -4.649%; -7.876%, -1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (-0.145 & mu;g/l; -0.279 & mu;g/l, -0.005 & mu;g/l). No associations were found with birthweight or other cord blood parameters.ConclusionsMaternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16681
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165961368&doi=10.1038%2fs41366-023-01347-9&partnerID=40&md5=2871c4dcd2401b7274302e3b15011950
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16681
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165961368&doi=10.1038%2fs41366-023-01347-9&partnerID=40&md5=2871c4dcd2401b7274302e3b15011950
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGERNATURE
publisher.none.fl_str_mv SPRINGERNATURE
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF OBESITY
ISSN: 03070565
ISSNe: 14765497
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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