Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters

Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnan...

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Detalles Bibliográficos
Autores: Dieberger, Anna Maria|||0000-0002-4102-3829, Obermayer-Pietsch, Barbara Maria, Harreiter, Jürgen|||0000-0003-2508-9403, Desoye, Gernot|||0000-0002-5715-3230, Van Poppel, Mireille|||0000-0001-5694-4324, Simmons, David Sean, Corcoy i Pla, Rosa|||0000-0001-5055-6814, Perez, Juan M. Adelantado, Kautzky-Willer, Alexandra|||0000-0002-3520-4105, Damm, Peter P., Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863, Jensen, Dorte M.|||0000-0002-3298-9824, Andersen, Lise-Lotte|||0000-0003-2997-2228, Dunne, Fidelma|||0000-0003-3682-9403, Lapolla, Annunziata, Dalfra, Maria Grazia|||0000-0002-3011-0521, Bertolotto, Alessandra|||0000-0003-1578-5421, Jelsma, Judith G. M.|||0000-0001-7943-9160, Galjaard, Sander|||0000-0002-4254-6664, Wender-Ozegowska, Ewa|||0000-0002-5492-8651, Zawiejska, Agnieszka|||0000-0002-3616-6550, Hill, David J.|||0000-0002-2490-5678, Devlieger, Roland|||0000-0001-7837-4684, Snoek, Frank|||0000-0001-9563-6762
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:303455
Acceso en línea:https://ddd.uab.cat/record/303455
https://dx.doi.org/urn:doi:10.1038/s41366-023-01347-9
Access Level:acceso abierto
Palabra clave:Adiposity
Bayes Theorem
Birth Weight
Body Mass Index
C-Peptide
Child
Exercise
Female
Fetal Blood
Humans
Infant, Newborn
Male
Pediatric Obesity
Pregnancy
Sedentary Behavior
Descripción
Sumario:Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (-0.520%; 95% CI: -1.011%, -0.031% and -4.649%; -7.876%, -1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (-0.145 µg/l; -0.279 µg/l, -0.005 µg/l). No associations were found with birthweight or other cord blood parameters. Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.

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