Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles

Krause’s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part o...

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Autores: Cuendias, Patricia, Vega, José A., García-Suárez, Olivia, Suazo, Iván, Cobo, Ramón, García Piqueras, Jorge, García-Mesa, Yolanda
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/729340
Acceso en línea:https://hdl.handle.net/10486/729340
https://dx.doi.org/10.3390/ijms25126722
Access Level:acceso abierto
Palabra clave:Krause’s corpuscles
terminal glial cells
PIEZO mechanoproteins
clitoris
human
Medicina
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spelling Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s CorpusclesCuendias, PatriciaVega, José A.García-Suárez, OliviaSuazo, IvánCobo, RamónGarcía Piqueras, JorgeGarcía-Mesa, YolandaKrause’s corpusclesterminal glial cellsPIEZO mechanoproteinsclitorishumanMedicinaKrause’s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause’s corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause’s corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus’s corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasureMDPIDepartamento de Anatomía, Histología y NeurocienciaFacultad de Medicina20242024-06-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/729340https://dx.doi.org/10.3390/ijms2512672238928429reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7293402026-06-23T12:46:27Z
dc.title.none.fl_str_mv Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
title Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
spellingShingle Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
Cuendias, Patricia
Krause’s corpuscles
terminal glial cells
PIEZO mechanoproteins
clitoris
human
Medicina
title_short Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
title_full Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
title_fullStr Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
title_full_unstemmed Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
title_sort Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles
dc.creator.none.fl_str_mv Cuendias, Patricia
Vega, José A.
García-Suárez, Olivia
Suazo, Iván
Cobo, Ramón
García Piqueras, Jorge
García-Mesa, Yolanda
author Cuendias, Patricia
author_facet Cuendias, Patricia
Vega, José A.
García-Suárez, Olivia
Suazo, Iván
Cobo, Ramón
García Piqueras, Jorge
García-Mesa, Yolanda
author_role author
author2 Vega, José A.
García-Suárez, Olivia
Suazo, Iván
Cobo, Ramón
García Piqueras, Jorge
García-Mesa, Yolanda
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía, Histología y Neurociencia
Facultad de Medicina
dc.subject.none.fl_str_mv Krause’s corpuscles
terminal glial cells
PIEZO mechanoproteins
clitoris
human
Medicina
topic Krause’s corpuscles
terminal glial cells
PIEZO mechanoproteins
clitoris
human
Medicina
description Krause’s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause’s corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause’s corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus’s corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasure
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-06-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/729340
https://dx.doi.org/10.3390/ijms25126722
38928429
url https://hdl.handle.net/10486/729340
https://dx.doi.org/10.3390/ijms25126722
identifier_str_mv 38928429
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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