The Glial Cell of human cutaneous sensory corpuscles: origin, characterization and putative roles
Sensory corpuscles of human skin are structures located at the peripheral end of the mechanoreceptive neurons and function as low-threshold mechanoreceptors (LTMRs). In its structure, in addition to the axon, there are glial cells, not myelinating, that are organized in different ways according to t...
| Autores: | , , , , , |
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| Tipo de recurso: | capítulo de libro |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Oviedo (UNIOVI) |
| Repositorio: | RUO. Repositorio Institucional de la Universidad de Oviedo |
| Idioma: | inglés |
| OAI Identifier: | oai:digibuo.uniovi.es:10651/76067 |
| Acceso en línea: | https://hdl.handle.net/10651/76067 https://dx.doi.org/10.5772/intechopen.91815 |
| Access Level: | acceso abierto |
| Palabra clave: | terminal glial cells, lamellar cells, Meissner corpuscles, pacinian corpuscles, human |
| Sumario: | Sensory corpuscles of human skin are structures located at the peripheral end of the mechanoreceptive neurons and function as low-threshold mechanoreceptors (LTMRs). In its structure, in addition to the axon, there are glial cells, not myelinating, that are organized in different ways according to the morphotype of sensitive corpuscle, forming the so-called laminar cells of Meissner’s corpuscles, the laminar cells of the inner core of Pacinian corpuscles, or cells of the inner core in Ruffini’s corpuscles. Classically the glial cells of sensory corpuscles have been considered support cells and passive in the process of mechanotransduction. However, the presence of ion channels and synapses-like systems between them and the axon suggests that corpuscular glial cells are actively involved in the transformation of mechanical into electrical impulses. This chapter is an update on the origin, development, cytoarchitecture, and protein profile of glial cells of sensitive corpuscles especially those of human glabrous skin. |
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