Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity

Cardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac func...

Descripción completa

Detalles Bibliográficos
Autor: Delgado Valero, Beatriz
Tipo de recurso: tesis doctoral
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/119052
Acceso en línea:https://hdl.handle.net/20.500.14352/119052
Access Level:acceso abierto
Palabra clave:616.61(043.2)
Galectina
Nefrología y urología
3205.06 Nefrología
id ES_de3255f8ced0f55ea46cf43bc626b903
oai_identifier_str oai:docta.ucm.es:20.500.14352/119052
network_acronym_str ES
network_name_str España
repository_id_str
spelling Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesityLa Galectina-3 promueve la activación del estrés de retículo endoplásmico a través de la disminución de let-7f-5p: relevancia en el daño renal post-infarto de miocardio en el contexto de la obesidadDelgado Valero, Beatriz616.61(043.2)GalectinaNefrología y urología3205.06 NefrologíaCardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac function leading to acute kidney injury [1], is known to have the highest incidence among the CRS diagnosed patients [2, 3]. Moreover, development of CRS-1 is known to increase hospitalization times and complicate clinical outcome in patients [4, 5].Although traditional cardiovascular risk factors such as hypertension, obesity or diabetes are believed to be implicated in the shared pathology of the heart and the kidneys, targeting only these factors in CRS-1 has shown unsatisfactory results [6], suggesting the need to assess non-conventional risk factors and other underlying mechanisms that could be relevant in the pathophysiology of CRS-induced renal damage...Universidad Complutense de MadridCachofeiro Ramos, María VictoriaMartínez Martínez, ErnestoUniversidad Complutense de Madrid20252025-03-3120252025-03-31doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/119052reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1190522026-06-02T12:44:21Z
dc.title.none.fl_str_mv Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
La Galectina-3 promueve la activación del estrés de retículo endoplásmico a través de la disminución de let-7f-5p: relevancia en el daño renal post-infarto de miocardio en el contexto de la obesidad
title Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
spellingShingle Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
Delgado Valero, Beatriz
616.61(043.2)
Galectina
Nefrología y urología
3205.06 Nefrología
title_short Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
title_full Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
title_fullStr Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
title_full_unstemmed Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
title_sort Galectin-3 promotes endoplasmic reticulum stress via let-7f-5p down regulation: Relevance in renal damage post-myocardial infarction in the context of obesity
dc.creator.none.fl_str_mv Delgado Valero, Beatriz
author Delgado Valero, Beatriz
author_facet Delgado Valero, Beatriz
author_role author
dc.contributor.none.fl_str_mv Cachofeiro Ramos, María Victoria
Martínez Martínez, Ernesto
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.61(043.2)
Galectina
Nefrología y urología
3205.06 Nefrología
topic 616.61(043.2)
Galectina
Nefrología y urología
3205.06 Nefrología
description Cardiorenal syndrome (CRS) represents a complex pathological interaction between the heart and the kidneys, where acute or chronic injury in one of them induces acute or chronic damage in the other. Out of the five subtypes, CRS type 1 (CRS-1), which is characterized by the worsening of cardiac function leading to acute kidney injury [1], is known to have the highest incidence among the CRS diagnosed patients [2, 3]. Moreover, development of CRS-1 is known to increase hospitalization times and complicate clinical outcome in patients [4, 5].Although traditional cardiovascular risk factors such as hypertension, obesity or diabetes are believed to be implicated in the shared pathology of the heart and the kidneys, targeting only these factors in CRS-1 has shown unsatisfactory results [6], suggesting the need to assess non-conventional risk factors and other underlying mechanisms that could be relevant in the pathophysiology of CRS-induced renal damage...
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-03-31
2025
2025-03-31
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/119052
url https://hdl.handle.net/20.500.14352/119052
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421951806603264
score 15,81155

Similares en LA Referencia