A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals

[EN] One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical(TM)) analogue-based therapies has a 3,4-dihy...

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Autores: López Prado, Mª Victoria, Sabater Picot, Mª José, Corma Canós, Avelino|||0000-0002-2232-3527
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/164994
Acceso en línea:https://riunet.upv.es/handle/10251/164994
Access Level:acceso abierto
Palabra clave:Pharmaceuticals
Dihydropyrimidinone
One-pot, synthesis
Bifunctional
Catalyst
QUIMICA ORGANICA
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repository_id_str
spelling A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of PharmaceuticalsLópez Prado, Mª VictoriaSabater Picot, Mª JoséCorma Canós, Avelino|||0000-0002-2232-3527PharmaceuticalsDihydropyrimidinoneOne-pot, synthesisBifunctionalCatalystQUIMICA ORGANICA[EN] One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical(TM)) analogue-based therapies has a 3,4-dihydropyrimidin-2(1H)-one (DHPM) scaffold and was obtained by means of a three one-pot process through successive oxidation, cyclocondensation and transesterification reactions. The one-pot strategy was extended to the synthesis of a series of related ester DHPM derivatives.Financial support by the Ministerio de Economia y Competitividad, Programa Severo Ochoa (SEV2016-0683) and Ministerio de Ciencia Innovacion y Universidades, Programa Estatal de Generacion de Conocimiento (PGC2018-101247-B-100) are gratefully acknowledged.Pleiades PublishingInstituto Universitario Mixto de Tecnología QuímicaMinisterio de Economía y CompetitividadAgencia Estatal de InvestigaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20202020-04-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/164994reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PGC2018-101247-B-I00 RECONOCIMIENTO MOLECULAR EN CATALIZADORES SOLIDOSMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 SEV-2016-0683open accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1649942026-06-13T07:49:27Z
dc.title.none.fl_str_mv A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
title A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
spellingShingle A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
López Prado, Mª Victoria
Pharmaceuticals
Dihydropyrimidinone
One-pot, synthesis
Bifunctional
Catalyst
QUIMICA ORGANICA
title_short A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
title_full A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
title_fullStr A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
title_full_unstemmed A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
title_sort A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals
dc.creator.none.fl_str_mv López Prado, Mª Victoria
Sabater Picot, Mª José
Corma Canós, Avelino|||0000-0002-2232-3527
author López Prado, Mª Victoria
author_facet López Prado, Mª Victoria
Sabater Picot, Mª José
Corma Canós, Avelino|||0000-0002-2232-3527
author_role author
author2 Sabater Picot, Mª José
Corma Canós, Avelino|||0000-0002-2232-3527
author2_role author
author
dc.contributor.none.fl_str_mv Instituto Universitario Mixto de Tecnología Química
Ministerio de Economía y Competitividad
Agencia Estatal de Investigación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Pharmaceuticals
Dihydropyrimidinone
One-pot, synthesis
Bifunctional
Catalyst
QUIMICA ORGANICA
topic Pharmaceuticals
Dihydropyrimidinone
One-pot, synthesis
Bifunctional
Catalyst
QUIMICA ORGANICA
description [EN] One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst. This molecule which has potential interest for the treatment of the obesity in orlistat (Xenical(TM)) analogue-based therapies has a 3,4-dihydropyrimidin-2(1H)-one (DHPM) scaffold and was obtained by means of a three one-pot process through successive oxidation, cyclocondensation and transesterification reactions. The one-pot strategy was extended to the synthesis of a series of related ester DHPM derivatives.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/164994
url https://riunet.upv.es/handle/10251/164994
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PGC2018-101247-B-I00 RECONOCIMIENTO MOLECULAR EN CATALIZADORES SOLIDOS
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 SEV-2016-0683
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pleiades Publishing
publisher.none.fl_str_mv Pleiades Publishing
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421888540770304
score 15.300719

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