Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility

The low solubility of drugs and nutraceuticals in water decreases their bioavailability, which poses a serious challenge to the biotechnology industry. To improve this, several mixtures have been proposed. Here, the solubility and antioxidant capacity of quercetin in binary mixtures of oleic acid wi...

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Autores: Gavín, Ana, Juan, Daniel, Muñoz-Embid, José, Haftbaradaran Esfahani, Mohammadreza, Lafuente, Carlos, Artal, Manuela
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:dnet:zaguan______::4dc91c53f4f286b031b606a393f2ef49
Acceso en línea:http://zaguan.unizar.es/record/170413
Access Level:acceso abierto
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spelling Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubilityGavín, AnaJuan, DanielMuñoz-Embid, JoséHaftbaradaran Esfahani, MohammadrezaLafuente, CarlosArtal, ManuelaThe low solubility of drugs and nutraceuticals in water decreases their bioavailability, which poses a serious challenge to the biotechnology industry. To improve this, several mixtures have been proposed. Here, the solubility and antioxidant capacity of quercetin in binary mixtures of oleic acid with geraniol and cinnamyl alcohol are determined. As a preliminary step, phase changes and thermophysical properties are discussed and modelled with the PC-SAFT EoS. The densities were between 6% at 283.15 K and 11% at 338.15 K lower than those of water. The surface tensions and viscosities were moderate and also decreased as the temperature increased. The equation of state correctly predicted the density and heat capacity, with average deviations less than 0.32% and 1.9%, respectively. The solubility of quercetin was favored in both mixtures. A synergistic effect on the antioxidant capacity was observed in the mixture with geraniol, which was the least compact.2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/170413reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/DGA/E31-23R-PLATONinfo:eu-repo/semantics/openAccessoai:dnet:zaguan______::4dc91c53f4f286b031b606a393f2ef492026-05-29T13:59:51Z
dc.title.none.fl_str_mv Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
title Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
spellingShingle Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
Gavín, Ana
title_short Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
title_full Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
title_fullStr Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
title_full_unstemmed Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
title_sort Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility
dc.creator.none.fl_str_mv Gavín, Ana
Juan, Daniel
Muñoz-Embid, José
Haftbaradaran Esfahani, Mohammadreza
Lafuente, Carlos
Artal, Manuela
author Gavín, Ana
author_facet Gavín, Ana
Juan, Daniel
Muñoz-Embid, José
Haftbaradaran Esfahani, Mohammadreza
Lafuente, Carlos
Artal, Manuela
author_role author
author2 Juan, Daniel
Muñoz-Embid, José
Haftbaradaran Esfahani, Mohammadreza
Lafuente, Carlos
Artal, Manuela
author2_role author
author
author
author
author
description The low solubility of drugs and nutraceuticals in water decreases their bioavailability, which poses a serious challenge to the biotechnology industry. To improve this, several mixtures have been proposed. Here, the solubility and antioxidant capacity of quercetin in binary mixtures of oleic acid with geraniol and cinnamyl alcohol are determined. As a preliminary step, phase changes and thermophysical properties are discussed and modelled with the PC-SAFT EoS. The densities were between 6% at 283.15 K and 11% at 338.15 K lower than those of water. The surface tensions and viscosities were moderate and also decreased as the temperature increased. The equation of state correctly predicted the density and heat capacity, with average deviations less than 0.32% and 1.9%, respectively. The solubility of quercetin was favored in both mixtures. A synergistic effect on the antioxidant capacity was observed in the mixture with geraniol, which was the least compact.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/170413
url http://zaguan.unizar.es/record/170413
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/DGA/E31-23R-PLATON
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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