Oleic acid: geraniol or cinnamyl alcohol hydrophobic mixtures: thermophysical properties and quercetin solubility

The low solubility of drugs and nutraceuticals in water decreases their bioavailability, which poses a serious challenge to the biotechnology industry. To improve this, several mixtures have been proposed. Here, the solubility and antioxidant capacity of quercetin in binary mixtures of oleic acid wi...

Full description

Bibliographic Details
Authors: Gavín, Ana, Juan, Daniel, Muñoz-Embid, José, Haftbaradaran Esfahani, Mohammadreza, Lafuente, Carlos, Artal, Manuela
Format: article
Status:Published version
Publication Date:2026
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:dnet:zaguan______::4dc91c53f4f286b031b606a393f2ef49
Online Access:http://zaguan.unizar.es/record/170413
Access Level:Open access
Description
Summary:The low solubility of drugs and nutraceuticals in water decreases their bioavailability, which poses a serious challenge to the biotechnology industry. To improve this, several mixtures have been proposed. Here, the solubility and antioxidant capacity of quercetin in binary mixtures of oleic acid with geraniol and cinnamyl alcohol are determined. As a preliminary step, phase changes and thermophysical properties are discussed and modelled with the PC-SAFT EoS. The densities were between 6% at 283.15 K and 11% at 338.15 K lower than those of water. The surface tensions and viscosities were moderate and also decreased as the temperature increased. The equation of state correctly predicted the density and heat capacity, with average deviations less than 0.32% and 1.9%, respectively. The solubility of quercetin was favored in both mixtures. A synergistic effect on the antioxidant capacity was observed in the mixture with geraniol, which was the least compact.