Photo-assembling cyclic peptides for dynamic light-driven peptide Nanotubes
Cyclic peptides containing a β-unsaturated amino acid are programmed to switch between monomeric form and self-assembled peptide nanotube structures upon light irradiation. The process is triggered by the reversible E-Z isomerization of the unsaturated β-amino acid that forces the peptide to swap fr...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/39030 |
| Acceso en línea: | https://hdl.handle.net/10347/39030 |
| Access Level: | acceso abierto |
| Palabra clave: | Nanotubos de péptidos Fotoensambladores Isomerización luz-inducida Polímeros supramoleculares Microfluidos 2306 Química orgánica |
| Sumario: | Cyclic peptides containing a β-unsaturated amino acid are programmed to switch between monomeric form and self-assembled peptide nanotube structures upon light irradiation. The process is triggered by the reversible E-Z isomerization of the unsaturated β-amino acid that forces the peptide to swap from the folded (unassembled) to the flat conformation (assembled). The process is also tuned by the pH media, which provides a double checkpoint control in the molecular assembly of the peptide nanotubes. The light-driven assembly process can be triggered in a confined environment, and the resulting nanotubes allow the inter-vesicle communication, providing droplets with self-fusiogenic properties. |
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