The plasma membrane as a mechanochemical transducer

Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical...

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Detalles Bibliográficos
Autores: Roux, Anabel-Lise Le, Quiroga, Xarxa, Walani, Nikhil, Arroyo, Marino, Roca-Cusachs Soulere, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/139038
Acceso en línea:https://hdl.handle.net/2445/139038
Access Level:acceso abierto
Palabra clave:Membranes cel·lulars
Càncer
Cell membranes
Cancer
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spelling The plasma membrane as a mechanochemical transducerRoux, Anabel-Lise LeQuiroga, XarxaWalani, NikhilArroyo, MarinoRoca-Cusachs Soulere, PereMembranes cel·lularsCàncerCell membranesCancerCells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment.The Royal Society Publishing2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/139038Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésPhilosophical Transactions of the Royal Society B: Biological Sciences, 2019, vol. 374, num. 1779, p. 20180221https://doi.org/10.1098/rstb.2018.0221info:eu-repo/grantAgreement/EC/H2020/731957info:eu-repo/grantAgreement/EC/ERC/681434cc by (c) Roux et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1390382026-05-27T06:46:51Z
dc.title.none.fl_str_mv The plasma membrane as a mechanochemical transducer
title The plasma membrane as a mechanochemical transducer
spellingShingle The plasma membrane as a mechanochemical transducer
Roux, Anabel-Lise Le
Membranes cel·lulars
Càncer
Cell membranes
Cancer
title_short The plasma membrane as a mechanochemical transducer
title_full The plasma membrane as a mechanochemical transducer
title_fullStr The plasma membrane as a mechanochemical transducer
title_full_unstemmed The plasma membrane as a mechanochemical transducer
title_sort The plasma membrane as a mechanochemical transducer
dc.creator.none.fl_str_mv Roux, Anabel-Lise Le
Quiroga, Xarxa
Walani, Nikhil
Arroyo, Marino
Roca-Cusachs Soulere, Pere
author Roux, Anabel-Lise Le
author_facet Roux, Anabel-Lise Le
Quiroga, Xarxa
Walani, Nikhil
Arroyo, Marino
Roca-Cusachs Soulere, Pere
author_role author
author2 Quiroga, Xarxa
Walani, Nikhil
Arroyo, Marino
Roca-Cusachs Soulere, Pere
author2_role author
author
author
author
dc.subject.none.fl_str_mv Membranes cel·lulars
Càncer
Cell membranes
Cancer
topic Membranes cel·lulars
Càncer
Cell membranes
Cancer
description Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/139038
url https://hdl.handle.net/2445/139038
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Philosophical Transactions of the Royal Society B: Biological Sciences, 2019, vol. 374, num. 1779, p. 20180221
https://doi.org/10.1098/rstb.2018.0221
info:eu-repo/grantAgreement/EC/H2020/731957
info:eu-repo/grantAgreement/EC/ERC/681434
dc.rights.none.fl_str_mv cc by (c) Roux et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Roux et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society Publishing
publisher.none.fl_str_mv The Royal Society Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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